Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha(2)-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences.

Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes.

Regulation of alpha2AR trafficking and signaling by interacting proteins.

Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization.

Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation.

Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor.

Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.

The receptor concept: a continuing evolution.

Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles.

Calmodulin interacts with the V2 vasopressin receptor: elimination of binding to the C terminus also eliminates arginine vasopressin-stimulated elevation of intracellular calcium.

Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs.

Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.

Membrane trafficking of G protein-coupled receptors.

Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves a conformation of the receptor that also attains mature glycosylation.

Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.

Synergies at the synapse.

Regulated interactions of the alpha 2A adrenergic receptor with spinophilin, 14-3-3zeta, and arrestin 3.

Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine.

Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.

G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction.