Structural insights into G-protein-coupled receptor activation.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

A monoclonal antibody for G protein-coupled receptor crystallography.

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Conformational complexity of G-protein-coupled receptors.

N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes.

Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes.

Counting low-copy number proteins in a single cell.

G protein coupled receptor structure and activation.

Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.

Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization.

Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability.

Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes.

A fluorescent probe designed for studying protein conformational change.

The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.

Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.

Myocyte adrenoceptor signaling pathways.

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.