The pitfalls of profoundly effective analgesic therapies.

Blockade of cytosolic phospholipase A(2)alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.

A toolbox facilitating stable transfection of Eimeria species.

In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response.

Blunt neck trauma: torn internal jugular vein after a motor vehicle crash.

Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.

Inflammatory markers and secondhand tobacco smoke exposure among U.S. workers.

Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study.

Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes.

Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision.

Understanding methadone metabolism: a foundation for safer use.

Respiratory effects of secondhand smoke exposure among young adults residing in a "clean" indoor air state.

Declining trends in serum cotinine levels in US worker groups: the power of policy.

Effect of anti-NGF antibodies in a rat tibia fracture model of complex regional pain syndrome type I.

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.

Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder.

Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan.

Managed clinical networks: what are they and how do they work?

Morphine reduces local cytokine expression and neutrophil infiltration after incision.