Official Symbol

ADRA2Bprovided by HGNC

Official Full Name

adrenergic, alpha-2B-, receptorprovided by HGNC

Primary source

HGNC:282

See related

HPRD:00086; MIM:104260

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; ADRA2B

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 2; Location: 2p13-q13See ADRA2B in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Observational study of gene-disease association. (HuGE Navigator)

2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

3. A vascular smooth muscle cell line stably expressing the human alpha 2B-adrenoceptor was generated by transfection of rat cells

4. Observational study of gene-disease association. (HuGE Navigator)

5. These data indicate that alpha-2 adrenergic receptors contribute significantly to CBR-induced vasoconstriction in the human leg under resting conditions.

6. Observational study of gene-disease association. (HuGE Navigator)

7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

9. Observational study of gene-disease association. (HuGE Navigator)

10. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

11. Observational study of gene-disease association. (HuGE Navigator)

12. Observational study of gene-disease association. (HuGE Navigator)

13. Observational study of gene-disease association. (HuGE Navigator)

14. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

15. Observational study of gene-disease association. (HuGE Navigator)

16. Observational study of gene-disease association. (HuGE Navigator)

17. Observational study of gene-disease association. (HuGE Navigator)

18. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

19. Observational study of gene-disease association. (HuGE Navigator)

20. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

21. Observational study of gene-disease association. (HuGE Navigator)

22. Observational study of gene-environment interaction. (HuGE Navigator)

23. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

24. Observational study of gene-disease association. (HuGE Navigator)

25. Observational study of genotype prevalence. (HuGE Navigator)

26. Observational study of gene-disease association. (HuGE Navigator)

27. Observational study of gene-disease association. (HuGE Navigator)

28. Observational study of gene-disease association. (HuGE Navigator)

29. Observational study of gene-disease association. (HuGE Navigator)

30. Observational study of gene-disease association. (HuGE Navigator)

31. Observational study of gene-environment interaction. (HuGE Navigator)

32. Observational study of gene-disease association. (HuGE Navigator)

33. Observational study of gene-disease association. (HuGE Navigator)

34. Observational study of gene-disease association. (HuGE Navigator)

35. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

36. a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor, is related to enhanced emotional memory in healthy Swiss subjects and in survivors of the Rwandan civil war who experienced highly aversive emotional situations.

37. {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue is inhibited by long chain fatty acids

38. alpha-2CDel AR appears to play only a minor role in presynaptic regulation of NA release and/or to be not hypofunctional in vivo in humans, but functional responsiveness of presynaptic alpha-2 AR declines with ageing.

39. study showed that genotype distribution and the frequency of the alpha 2 beta adrenergic receptor alleles was not different in Greek women with polycystic ovary syndrome and controls

40. main finding was that men with the DD polymorphism of the ADRA2B gene and job strain have significantly higher blood pressure than all other gene-work characteristics combinations

41. The decrease in intermuscular fat (IMF) in ADRalpha2bGlu9 carriers was significantly different from a nonsignificant increase in ADRalpha2bGlu9 noncarriers.

42. The 12Glu9 polymorphism of ADRA2B is associated with impaired insulin secretion and may predict the development of Type 2 diabetes.

43. No major functional significance of the alpha(2B) adrenergic receptor polymorphism in the present sample of morbidly obese subjects was found.

44. Middle-aged white men carrying the DD genotype of the alpha(2B)-AR have a significantly increased risk for sudden cardiac death and myocardial infarction, especially before the age of 55 years.

45. Leisure-time physical activity decreased the risk of type 2 diabetes in those with the 12Glu and 9Glu alleles of the ADRA2B gene.

46. the del301-303 polymorphism of ADRA2B does not contribute significantly to interindividual in vivo variability in response to alpha2-AR activation in the hand vein

47. Evidence for an association of the D allele with both presence and severity of neuropathy in patients with type 2 diabetes mellitus.

48. In Chinese men, the I allele of the ADRA2B gene is associated with higher blood pressure, but also with a more favourable metabolic phenotype.

49. A polymorphism in the (alpha)2B adrenoceptor gene associates with hypertension.

50. analysis of stability of ADRA2B and binding to small molecules after detergent solubilization

51. body fat response to exercise training in older adults is associated with the combined effects of the Glu12/Glu9 alpha2b-adrenergic receptor, Trp64Arg beta3-adrenergic receptor, and Gln27Glu beta2-adrenergic receptor gene variants

52. Multiple stepwise linear regression identified alpha2B genotype as an independent predictor of age at onset of type 2 diabetes.

53. ADRA2A and ADRA2B each had a single haplotype block at least 11 and 16 kb in size

54. Alpha2-ARs in vascular smooth muscle cells reflect differential activity of alpha2-AR gene promoters. Alpha2C-ARs can be induced via p38 MAPK-dependent pathway.

Markers

Pathways

Homology

GeneOntology Provided by GOA

Preferred Names

alpha-2B-adrenergic receptor

Names

alpha-2B-adrenergic receptor

G-protein coupled receptor

adrenergic receptor alpha 2B

alpha-2-adrenergic receptor-like 1

ADRA2B adrenergic, alpha-2B-, receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

RefSeqs of Annotated Genomes: Build 36.3

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly

Genomic

Alternate assembly (based on Celera assembly)

Genomic

Alternate assembly (based on HuRef)

Genomic