Ph: 12433513
Your browser version may not work well with NCBI's Web applications. More information here...
1: Lancet. 2002 Nov 9;360(9344):1455-61.
Related Articles, Links
Click here to read
Comment in:
ACP J Club. 2003 May-Jun;138(3):63. Evid Based Nurs. 2003 Jul;6(3):79. Lancet. 2005 Jul 30-Aug 5;366(9483):353-4. Lancet. 2005 Jul 30-Aug 5;366(9483):354-6. Lancet. 2005 Jul 30-Aug 5;366(9483):365-6; author reply 366-7.

Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial.

Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, Manor O, Pella D, Berry EM.

Centre of Nutrition and Heart, Medical Hospital and Research Centre, Moradabad, India.

BACKGROUND: The rapid emergence of coronary artery disease (CAD) in south Asian people is not explained by conventional risk factors. In view of cardioprotective effects of a Mediterranean style diet rich in alpha-linolenic acid, we assessed the benefits of this diet for patients at high risk of CAD. METHODS: We did a randomised, single-blind trial in 1000 patients with angina pectoris, myocardial infarction, or surrogate risk factors for CAD. 499 patients were allocated to a diet rich in whole grains, fruits, vegetables, walnuts, and almonds. 501 controls consumed a local diet similar to the step I National Cholesterol Education Program (NCEP) prudent diet. FINDINGS: The intervention group consumed more fruits, vegetables, legumes, walnuts, and almonds than did controls (573 g [SD 127] vs 231 g [19] per day p<0.001). The intervention group had an increased intake of whole grains and mustard or soy bean oil. The mean intake of alpha-linolenic acid was two-fold greater in the intervention group (1.8 g [SD 0.4] vs 0.8 g [0.2] per day, p<0.001). Total cardiac end points were significantly fewer in the intervention group than the controls (39 vs 76 events, p<0.001). Sudden cardiac deaths were also reduced (6 vs 16, p=0.015), as were non-fatal myocardial infarctions (21 vs 43, p<0.001). We noted a significant reduction in serum cholesterol concentration and other risk factors in both groups, but especially in the intervention diet group. In the treatment group, patients with pre-existing CAD had significantly greater benefits compared with such patients in the control group. INTERPRETATION: An Indo-Mediterranean diet that is rich in alpha-linolenic acid might be more effective in primary and secondary prevention of CAD than the conventional step I NCEP prudent diet.

Publication Types:
Clinical Trial Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

PMID: 12433513 [PubMed - indexed for MEDLINE]

You are viewing a mobilized version of this site...
View original page here

How do you rate mobile version of this page?

Mobilized by Mowser Mowser