NM_009633.3
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus18424752
REFERENCE   2  (residues 1 to 453)
  AUTHORS   Aihara,M., Lindsey,J.D. and Weinreb,R.N.
  TITLE     Effect on diurnal intraocular pressure variation of eliminating the
            alpha-2 adrenergic receptor subtypes in the mouse
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 49 (3), 929-933 (2008)
   PUBMED   18326714
REFERENCE   3  (residues 1 to 453)
  AUTHORS   Muthig,V., Gilsbach,R., Haubold,M., Philipp,M., Ivacevic,T.,
            Gessler,M. and Hein,L.
  TITLE     Upregulation of soluble vascular endothelial growth factor receptor
            1 contributes to angiogenesis defects in the placenta of alpha
            2B-adrenoceptor deficient mice
  JOURNAL   Circ. Res. 101 (7), 682-691 (2007)
   PUBMED   1767367417636168
REFERENCE   5  (residues 1 to 453)
  AUTHORS   Knaus,A., Zong,X., Beetz,N., Jahns,R., Lohse,M.J., Biel,M. and
            Hein,L.
  TITLE     Direct inhibition of cardiac hyperpolarization-activated cyclic
            nucleotide-gated pacemaker channels by clonidine
  JOURNAL   Circulation 115 (7), 872-880 (2007)
   PUBMED   17261653
REFERENCE   6  (residues 1 to 453)
  AUTHORS   Link,R.E., Desai,K., Hein,L., Stevens,M.E., Chruscinski,A.,
            Bernstein,D., Barsh,G.S. and Kobilka,B.K.
  TITLE     Cardiovascular regulation in mice lacking alpha2-adrenergic
            receptor subtypes b and c
  JOURNAL   Science 273 (5276), 803-805 (1996)
   PUBMED   8670422
REFERENCE   7  (residues 1 to 453)
  AUTHORS   Chang,N.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Chang,Y.H.,
            Chen,W.M. and Chang,A.C.
  TITLE     Assignment of two alpha 2 adrenoceptor subtype genes to murine
            chromosomes
  JOURNAL   Neurosci. Lett. 167 (1-2), 105-108 (1994)
   PUBMED   8177505
REFERENCE   8  (residues 1 to 453)
  AUTHORS   Link,R.E., Kobilka,B.K. and Barsh,G.S.
  TITLE     Linkage mapping of alpha-2 adrenergic receptor genes to mouse
            chromosomes 2 and 5
  JOURNAL   Mamm. Genome 4 (11), 650-655 (1993)
   PUBMED   8281014
REFERENCE   9  (residues 1 to 453)
  AUTHORS   Chen,W.M., Chang,A.C., Shie,B.J., Chang,Y.H. and Chang,N.C.
  TITLE     Molecular cloning and characterization of a mouse alpha 2C2
            adrenoceptor subtype gene
  JOURNAL   Biochim. Biophys. Acta 1171 (2), 219-223 (1992)
   PUBMED   13363961354956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731836.10.
            On Apr 26, 2004 this sequence version replaced gi:6752994.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no full-length high-quality transcript from the
            C57BL/6J reference strain was available. The extent of this
            transcript is supported by its existence in multiple strains.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.0 cM"
     Protein         1..453
                     /product="adrenergic receptor, alpha 2b"
                     /note="subtype alpha2-C2"
                     /calculated_mol_wt=50312
     CDS             1..453
                     /gene="Adra2b"
                     /gene_synonym="[a]2B"
                     /gene_synonym="Adra-2b"
                     /gene_synonym="alpha2B"
                     /gene_synonym="alpha2-C2"
                     /coded_by="NM_009633.3:280..1641"
                     /db_xref="CCDS:CCDS16701.1"
                     /db_xref="GeneID:11552"
                     /db_xref="MGI:87935"
ORIGIN      
        1 msgpamvhqe pysvqataai asaitflilf tifgnalvil avltsrslra pqnlflvsla
       61 aadilvatli ipfslanell gywyfwrawc evylaldvlf ctssivhlca isldrywavs
      121 raleynskrt prrikciilt vwliaavisl ppliykgdqr pephglpqce lnqeawyila
      181 ssigsffapc limilvylri yviakrshcr glgakrgsge geskkphpaa ggvpasakvp
      241 tlvsplssvg eanghpkppr ekeegetped pearalppnw salprsvqdq kkgtsgatae
      301 kgaeedeeev eecepqtlpa spasvfnppl qqpqtsrvla tlrgqvllsk nvgvasgqww
      361 rrrtqlsrek rftfvlavvi gvfvvcwfpf ffsyslgaic pqhckvphgl fqfffwigyc
      421 nsslnpviyt ifnqdfrraf rrilcrqwtq tgw
//

REFERENCE   10 (residues 1 to 453)
  AUTHORS   Chruscinski,A.J., Link,R.E., Daunt,D.A., Barsh,G.S. and
            Kobilka,B.K.
  TITLE     Cloning and expression of the mouse homolog of the human alpha 2-C2
            adrenergic receptor
  JOURNAL   Biochem. Biophys. Res. Commun. 186 (3), 1280-1287 (1992)
   PUBMED   
  REMARK    GeneRIF: alpha2B adrenoceptor deficient mice develop a defect in
            fetal and maternal vessel formation in the placenta.
REFERENCE   4  (residues 1 to 453)
  AUTHORS   Cikos,S., Rehak,P., Czikkova,S., Vesela,J. and Koppel,J.
  TITLE     Expression of adrenergic receptors in mouse preimplantation embryos
            and ovulated oocytes
  JOURNAL   Reproduction 133 (6), 1139-1147 (2007)
   PUBMED   
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (residues 1 to 453)
  AUTHORS   Takedachi,M., Qu,D., Ebisuno,Y., Oohara,H., Joachims,M.L.,
            McGee,S.T., Maeda,E., McEver,R.P., Tanaka,T., Miyasaka,M.,
            Murakami,S., Krahn,T., Blackburn,M.R. and Thompson,L.F.
  TITLE     CD73-generated adenosine restricts lymphocyte migration into
            draining lymph nodes
  JOURNAL   J. Immunol. 180 (9), 6288-6296 (2008)
   PUBMED   
LOCUS       NP_033763                453 aa            linear   ROD 29-JUN-2008
DEFINITION  adrenergic receptor, alpha 2b [Mus musculus].
ACCESSION   NP_033763
VERSION     NP_033763.2  GI:46575786
DBSOURCE    REFSEQ: accession