NM_000682.5
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens18854756
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   2  (residues 1 to 450)
  AUTHORS   Tikhonoff,V., Hasenkamp,S., Kuznetsova,T., Thijs,L., Jin,Y.,
            Richart,T., Zhang,H., Brand-Herrmann,S.M., Brand,E., Casiglia,E.
            and Staessen,J.A.
  TITLE     Blood pressure and metabolic phenotypes in relation to the ADRB1
            Arg389Gly and ADRA2B I/D polymorphisms in a White population
  JOURNAL   J Hum Hypertens (2008) In press
   PUBMED   18596718
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 450)
  AUTHORS   Huhtinen,A. and Scheinin,M.
  TITLE     Expression and characterization of the human alpha 2B-adrenoceptor
            in a vascular smooth muscle cell line
  JOURNAL   Eur. J. Pharmacol. 587 (1-3), 48-56 (2008)
   PUBMED   18456256
  REMARK    GeneRIF: A vascular smooth muscle cell line stably expressing the
            human alpha 2B-adrenoceptor was generated by transfection of rat
            cells
REFERENCE   4  (residues 1 to 450)
  AUTHORS   Wray,D.W., Raven,P.B. and Sander,M.
  TITLE     Diminished baroreflex-induced vasoconstriction following alpha-2
            adrenergic receptor blockade in humans
  JOURNAL   Auton Neurosci 138 (1-2), 114-117 (2008)
   PUBMED   18054844
  REMARK    GeneRIF: These data indicate that alpha-2 adrenergic receptors
            contribute significantly to CBR-induced vasoconstriction in the
            human leg under resting conditions.
REFERENCE   5  (residues 1 to 450)
  AUTHORS   Vasudevan,R., Ismail,P., Stanslas,J., Shamsudin,N. and Ali,A.B.
  TITLE     Association of insertion/deletion polymorphism of
            alpha-adrenoceptor gene in essential hypertension with or without
            type 2 diabetes mellitus in Malaysian subjects
  JOURNAL   Int. J. Biol. Sci. 4 (6), 362-367 (2008)
   PUBMED   18953403
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 450)
  AUTHORS   Weinshank,R.L., Zgombick,J.M., Macchi,M., Adham,N., Lichtblau,H.,
            Branchek,T.A. and Hartig,P.R.
  TITLE     Cloning, expression, and pharmacological characterization of a
            human alpha 2B-adrenergic receptor
  JOURNAL   Mol. Pharmacol. 38 (5), 681-688 (1990)
   PUBMED   2172775
REFERENCE   7  (residues 1 to 450)
  AUTHORS   Chang,A.C., Ho,T.F. and Chang,N.C.
  TITLE     In vitro amplification by polymerase chain reaction of a partial
            gene encoding the third subtype of alpha-2 adrenergic receptor in
            humans
  JOURNAL   Biochem. Biophys. Res. Commun. 172 (2), 817-823 (1990)
   PUBMED   2173582
REFERENCE   8  (residues 1 to 450)
  AUTHORS   McClue,S.J. and Milligan,G.
  TITLE     The alpha 2B adrenergic receptor of undifferentiated neuroblastoma
            x glioma hybrid NG108-15 cells, interacts directly with the guanine
            nucleotide binding protein, Gi2
  JOURNAL   FEBS Lett. 269 (2), 430-434 (1990)
   PUBMED   216943421642212842764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY548167.1, CV806541.1,
            AC092603.2 and AA887330.1.
            On Aug 12, 2003 this sequence version replaced gi:4501965.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. They include 3 highly
            homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
            have a critical role in regulating neurotransmitter release from
            sympathetic nerves and from adrenergic neurons in the central
            nervous system. This gene encodes the alpha2B subtype, which was
            observed to associate with eIF-2B, a guanine nucleotide exchange
            protein that functions in regulation of translation. A polymorphic
            variant of the alpha2B subtype, which lacks 3 glutamic acids from a
            glutamic acid repeat element, was identified to have decreased G
            protein-coupled receptor kinase-mediated phosphorylation and
            desensitization; this polymorphic form is also associated with
            reduced basal metabolic rate in obese subjects and may therefore
            contribute to the pathogenesis of obesity. This gene contains no
            introns in either its coding or untranslated sequences. [provided
            by RefSeq].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13-q13"
     Protein         1..450
                     /product="alpha-2B-adrenergic receptor"
                     /note="alpha-2-adrenergic receptor-like 1; G-protein
                     coupled receptor; adrenergic receptor alpha 2B; ADRA2B
                     adrenergic, alpha-2B-, receptor"
                     /calculated_mol_wt=49823
     Region          294..311
                     /region_name="Asp/Glu-rich domain"
     CDS             1..450
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /coded_by="NM_000682.5:1..1353"
                     /db_xref="GeneID:151"
                     /db_xref="HGNC:282"
                     /db_xref="HPRD:00086"
                     /db_xref="MIM:104260"
ORIGIN      
        1 mdhqdpysvq ataaiaaait flilftifgn alvilavlts rslrapqnlf lvslaaadil
       61 vatliipfsl anellgywyf rrtwcevyla ldvlfctssi vhlcaisldr ywavsraley
      121 nskrtprrik ciiltvwlia avislppliy kgdqgpqprg rpqcklnqea wyilassigs
      181 ffapclimil vylriyliak rsnrrgprak ggpgqgeskq prpdhggala saklpalasv
      241 asarevnghs kstgekeege tpedtgtral ppswaalpns gqgqkegvcg aspedeaeee
      301 eeeeeeeeec epqavpvspa sacspplqqp qgsrvlatlr gqvllgrgvg aiggqwwrrr
      361 aqltrekrft fvlavvigvf vlcwfpfffs yslgaicpkh ckvphglfqf ffwigycnss
      421 lnpviytifn qdfrrafrri lcrpwtqtaw
//

REFERENCE   10 (residues 1 to 450)
  AUTHORS   Regan,J.W., Kobilka,T.S., Yang-Feng,T.L., Caron,M.G.,
            Lefkowitz,R.J. and Kobilka,B.K.
  TITLE     Cloning and expression of a human kidney cDNA for an alpha
            2-adrenergic receptor subtype
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (17), 6301-6305 (1988)
   PUBMED   
REFERENCE   9  (residues 1 to 450)
  AUTHORS   Lomasney,J.W., Lorenz,W., Allen,L.F., King,K., Regan,J.W.,
            Yang-Feng,T.L., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Expansion of the alpha 2-adrenergic receptor family: cloning and
            characterization of a human alpha 2-adrenergic receptor subtype,
            the gene for which is located on chromosome 2
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5094-5098 (1990)
   PUBMED   
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 450)
  AUTHORS   Li,L.H., Li,Y., Wen,Y. and Wang,J.G.
  TITLE     Anthropometric and metabolic phenotypes in relation to the ADRA2B
            deletion/insertion polymorphism in Chinese population
  JOURNAL   J. Hypertens. 26 (11), 2161-2167 (2008)
   PUBMED   
LOCUS       NP_000673                450 aa            linear   PRI 16-NOV-2008
DEFINITION  alpha-2B-adrenergic receptor [Homo sapiens].
ACCESSION   NP_000673
VERSION     NP_000673.2  GI:33598960
DBSOURCE    REFSEQ: accession