NM_000681.3
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Wakeno,M., Kato,M., Okugawa,G., Fukuda,T., Hosoi,Y., Takekita,Y.,
            Yamashita,M., Nonen,S., Azuma,J. and Kinoshita,T.
  TITLE     The alpha 2A-adrenergic receptor gene polymorphism modifies
            antidepressant responses to milnacipran
  JOURNAL   J Clin Psychopharmacol 28 (5), 518-524 (2008)
   PUBMED   1879464618725220
  REMARK    GeneRIF: Clinical trial of gene-disease association, gene-gene
            interaction, gene-environment interaction, and pharmacogenomic /
            toxicogenomic. (HuGE Navigator)
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Yabe,M., Matsubara,Y., Takahashi,S., Ishihara,H., Shibano,T.,
            Watanabe,G., Murata,M. and Ikeda,Y.
  TITLE     Alpha 2A adrenergic receptor polymorphism is associated with plasma
            von Willebrand factor levels in a general population
  JOURNAL   Blood Coagul. Fibrinolysis 19 (5), 395-399 (2008)
   PUBMED   18600088
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Tanabe,M.
  TITLE     [Imidazoline receptor]
  JOURNAL   Nippon Yakurigaku Zasshi 131 (6), 478-480 (2008)
   PUBMED   18561481
  REMARK    GeneRIF: shows strong affinity to idazoxan and excists in MAO of
            mitochondria which has imidazoline-ligand binding sites in its
            molecule.
            Review article
REFERENCE   5  (residues 1 to 465)
  AUTHORS   Karahalil,B., Coskun,E. and Emerce,E.
  TITLE     ADRA2A polymorphism and smoking in a Turkish population
  JOURNAL   Toxicol Ind Health 24 (3), 171-176 (2008)
   PUBMED   188426951385431
REFERENCE   7  (residues 1 to 465)
  AUTHORS   Perala,M., Hirvonen,H., Kalimo,H., Ala-Uotila,S., Regan,J.W.,
            Akerman,K.E. and Scheinin,M.
  TITLE     Differential expression of two alpha 2-adrenergic receptor subtype
            mRNAs in human tissues
  JOURNAL   Brain Res. Mol. Brain Res. 16 (1-2), 57-63 (1992)
   PUBMED   1334200
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Surprenant,A., Horstman,D.A., Akbarali,H. and Limbird,L.E.
  TITLE     A point mutation of the alpha 2-adrenoceptor that blocks coupling
            to potassium but not calcium currents
  JOURNAL   Science 257 (5072), 977-980 (1992)
   PUBMED   13543941678390
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Wang,C.D., Buck,M.A. and Fraser,C.M.
  TITLE     Site-directed mutagenesis of alpha 2A-adrenergic receptors:
            identification of amino acids involved in ligand binding and
            receptor activation by agonists
  JOURNAL   Mol. Pharmacol. 40 (2), 168-179 (1991)
   PUBMED   1678850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158163.11, AF284095.1 and
            BM682651.1.
            On Jul 22, 2008 this sequence version replaced gi:15718670.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. They include 3 highly
            homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
            have a critical role in regulating neurotransmitter release from
            sympathetic nerves and from adrenergic neurons in the central
            nervous system. Studies in mouse revealed that both the alpha2A and
            alpha2C subtypes were required for normal presynaptic control of
            transmitter release from sympathetic nerves in the heart and from
            central noradrenergic neurons; the alpha2A subtype inhibited
            transmitter release at high stimulation frequencies, whereas the
            alpha2C subtype modulated neurotransmission at lower levels of
            nerve activity. This gene encodes alpha2A subtype and it contains
            no introns in either its coding or untranslated sequences.
            [provided by RefSeq].
            
            Sequence Note: The 5'-most in-frame translation initiation codon is
            selected for this RefSeq based on good conservation across
            mammalian species. A possible downstream start codon would result
            in a protein that is 15 aa shorter at the N-terminus. The
            literature, including PMIDs:2823383, 2568356, 1354394 and 1678390,
            assumes the use of the downstream start codon based on initial
            cloning reports, but there is no experimental evidence indicating
            which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24-q26"
     Protein         1..465
                     /product="alpha-2A-adrenergic receptor"
                     /note="alpha-2AAR subtype C10; alpha2A adrenergic
                     receptor; alpha-2-adrenergic receptor, platelet type;
                     alpha-2A adrenoceptor"
                     /calculated_mol_wt=50516
     Region          16
                     /region_name="alternative translation initiation codon"
     CDS             1..465
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /coded_by="NM_000681.3:966..2363"
                     /db_xref="CCDS:CCDS7569.1"
                     /db_xref="GeneID:150"
                     /db_xref="HGNC:281"
                     /db_xref="HPRD:00078"
                     /db_xref="MIM:104210"
ORIGIN      
        1 mfrqeqplae gsfapmgslq pdagnaswng teapgggara tpyslqvtlt lvclagllml
       61 ltvfgnvlvi iavftsralk apqnlflvsl asadilvatl vipfslanev mgywyfgkaw
      121 ceiylaldvl fctssivhlc aisldrywsi tqaieynlkr tprrikaiii tvwvisavis
      181 fpplisiekk gggggpqpae prceindqkw yvisscigsf fapclimilv yvriyqiakr
      241 rtrvppsrrg pdavaappgg terrpnglgp ersagpggae aeplptqlng apgepapagp
      301 rdtdaldlee ssssdhaerp pgprrpergp rgkgkarasq vkpgdslprr gpgatgigtp
      361 aagpgeervg aakasrwrgr qnrekrftfv lavvigvfvv cwfpffftyt ltavgcsvpr
      421 tlfkfffwfg ycnsslnpvi ytifnhdfrr afkkilcrgd rkriv
//

REFERENCE   9  (residues 1 to 465)
  AUTHORS   Suryanarayana,S., Daunt,D.A., Von Zastrow,M. and Kobilka,B.K.
  TITLE     A point mutation in the seventh hydrophobic domain of the alpha 2
            adrenergic receptor increases its affinity for a family of beta
            receptor antagonists
  JOURNAL   J. Biol. Chem. 266 (23), 15488-15492 (1991)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Handy,D.E. and Gavras,H.
  TITLE     Promoter region of the human alpha 2A adrenergic receptor gene
  JOURNAL   J. Biol. Chem. 267 (33), 24017-24022 (1992)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Grudell,A.B., Sweetser,S., Camilleri,M., Eckert,D.J.,
            Vazquez-Roque,M.I., Carlson,P.J., Burton,D.D., Braddock,A.E.,
            Clark,M.M., Graszer,K.M., Kalsy,S.A. and Zinsmeister,A.R.
  TITLE     A controlled pharmacogenetic trial of sibutramine on weight loss
            and body composition in obese or overweight adults
  JOURNAL   Gastroenterology 135 (4), 1142-1154 (2008)
   PUBMED   
LOCUS       NP_000672                465 aa            linear   PRI 16-NOV-2008
DEFINITION  alpha-2A-adrenergic receptor [Homo sapiens].
ACCESSION   NP_000672
VERSION     NP_000672.3  GI:194353970
DBSOURCE    REFSEQ: accession