NM_000579.3
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 352)
  AUTHORS   Singh,K.K., Hughes,M.D., Chen,J., Phiri,K., Rousseau,C., Kuhn,L.,
            Coutsoudis,A., Jackson,J.B., Guay,L.A., Musoke,P., Mmiro,F.,
            Semba,R.D. and Spector,S.A.
  TITLE     Associations of chemokine receptor polymorphisms With HIV-1
            mother-to-child transmission in sub-Saharan Africa: possible
            modulation of genetic effects by antiretrovirals
  JOURNAL   J. Acquir. Immune Defic. Syndr. 49 (3), 259-265 (2008)
   PUBMED   18845960
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (residues 1 to 352)
  AUTHORS   Reiche,E.M., Ehara Watanabe,M.A., Bonametti,A.M., Morimoto,H.K.,
            Akira Morimoto,A., Wiechmann,S.L., Matsuo,T., Carvalho De
            Oliveira,J. and Vissoci Reiche,F.
  TITLE     Frequency of CCR5-Delta32 deletion in human immunodeficiency virus
            type 1 (HIV-1) in healthy blood donors, HIV-1-exposed seronegative
            and HIV-1-seropositive individuals of southern Brazilian population
  JOURNAL   Int. J. Mol. Med. 22 (5), 669-675 (2008)
   PUBMED   18949389
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (residues 1 to 352)
  AUTHORS   Wang,Y., Wang,X., Peng,J., Chen,L., Cheng,J., Nie,S., Feng,T.,
            Zhao,G., Zhao,J. and Shi,X.
  TITLE     SDF1-3'A Gene Mutation Is Correlated with Increased Susceptibility
            to HIV Type 1 Infection by Sexual Transmission in Han Chinese
  JOURNAL   AIDS Res. Hum. Retroviruses (2008) In press
   PUBMED   18928397
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 352)
  AUTHORS   Rigato,P.O., Hong,M.A., Casseb,J., Ueda,M., de Castro,I., Benard,G.
            and Duarte,A.J.
  TITLE     Better CD4+ T cell recovery in Brazilian HIV-infected individuals
            under HAART due to cumulative carriage of SDF-1-3'A, CCR2-V64I,
            CCR5-D32 and CCR5-promoter 59029A/G polymorphisms
  JOURNAL   Curr. HIV Res. 6 (5), 466-473 (2008)
   PUBMED   18855658
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 352)
  AUTHORS   Ganczak,M., Bohatyrewicz,A., Szych,Z. and Bialecki,P.
  TITLE     [Markers of hepatitis B, C and HIV among orthopedic patients and
            staff at a Polish university hospital]
  JOURNAL   Chir Narzadow Ruchu Ortop Pol 73 (2), 83-88 (2008)
   PUBMED   18846999117335801144895710085131
REFERENCE   9  (sites)
  AUTHORS   Farzan,M., Mirzabekov,T., Kolchinsky,P., Wyatt,R., Cayabyab,M.,
            Gerard,N.P., Gerard,C., Sodroski,J. and Choe,H.
  TITLE     Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1
            entry
  JOURNAL   Cell 96 (5), 667-676 (1999)
   PUBMED   100898822183196256946725643923346208
REFERENCE   14 (residues 1 to 352)
  AUTHORS   Brands,J.H., Maassen,J.A., van Hemert,F.J., Amons,R. and Moller,W.
  TITLE     The primary structure of the alpha subunit of human elongation
            factor 1. Structural aspects of guanine-nucleotide-binding sites
  JOURNAL   Eur. J. Biochem. 155 (1), 167-171 (1986)
   PUBMED   3512269
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098613.2, DA818906.1,
            U54994.1 and BC038398.1.
            On Jun 26, 2007 this sequence version replaced gi:113414883.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. This protein is expressed
            by T cells and macrophages, and is known to be an important
            co-receptor for macrophage-tropic virus, including HIV, to enter
            host cells. Defective alleles of this gene have been associated
            with the HIV infection resistance. The ligands of this receptor
            include monocyte chemoattractant protein 2 (MCP-2), macrophage
            inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory
            protein 1 beta (MIP-1 beta) and regulated on activation normal T
            expressed and secreted protein (RANTES). Expression of this gene
            was also detected in a promyeloblastic cell line, suggesting that
            this protein may play a role in granulocyte lineage proliferation
            and differentiation. This gene is located at the chemokine receptor
            gene cluster region. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq].
            
            Transcript Variant: This variant (A) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by published experimental evidence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     Protein         1..352
                     /product="chemokine (C-C motif) receptor 5"
                     /note="chemr13; chemokine (C-C) receptor 5; C-C chemokine
                     receptor 5; chemokine receptor CCR5; CCR5 chemokine
                     receptor; C-C chemokine receptor type 5"
                     /calculated_mol_wt=40393
     Site            3
                     /site_type="sulfatation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[9]
     Site            6
                     /site_type="glycosylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[6]
     Site            10
                     /site_type="sulfatation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[9]
     Site            14
                     /site_type="sulfatation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[9]
     Site            15
                     /site_type="sulfatation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[9]
     Site            321
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="palmitoylation site"
                     /citation=[7]
     Site            323
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="palmitoylation site"
                     /citation=[7]
     Site            324
                     /site_type="modified"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="palmitoylation site"
                     /citation=[7]
     Site            336
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[8]
                     /db_xref="HPRD:00183"
     Site            337
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[8]
                     /db_xref="HPRD:00183"
     Site            342
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[8]
                     /db_xref="HPRD:00183"
     Site            349
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[8]
                     /db_xref="HPRD:00183"
     CDS             1..352
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /coded_by="NM_000579.3:358..1416"
                     /db_xref="CCDS:CCDS2739.1"
                     /db_xref="GeneID:1234"
                     /db_xref="HGNC:1606"
                     /db_xref="HPRD:03223"
                     /db_xref="MIM:601373"
ORIGIN      
        1 mdyqvsspiy dinyytsepc qkinvkqiaa rllpplyslv fifgfvgnml vililinckr
       61 lksmtdiyll nlaisdlffl ltvpfwahya aaqwdfgntm cqlltglyfi gffsgiffii
      121 lltidrylav vhavfalkar tvtfgvvtsv itwvvavfas lpgiiftrsq keglhytcss
      181 hfpysqyqfw knfqtlkivi lglvlpllvm vicysgilkt llrcrnekkr hravrlifti
      241 mivyflfwap ynivlllntf qeffglnncs ssnrldqamq vtetlgmthc cinpiiyafv
      301 gekfrnyllv ffqkhiakrf ckccsifqqe aperassvyt rstgeqeisv gl
//

REFERENCE   13 (residues 1 to 352)
  AUTHORS   Ann,D.K., Wu,M.M., Huang,T., Carlson,D.M. and Wu,R.
  TITLE     Retinol-regulated gene expression in human tracheobronchial
            epithelial cells. Enhanced expression of elongation factor EF-1
            alpha
  JOURNAL   J. Biol. Chem. 263 (8), 3546-3549 (1988)
   PUBMED   
REFERENCE   12 (residues 1 to 352)
  AUTHORS   Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
  TITLE     Isolation and characterization of the human chromosomal gene for
            polypeptide chain elongation factor-1 alpha
  JOURNAL   J. Biol. Chem. 264 (10), 5791-5798 (1989)
   PUBMED   
REFERENCE   11 (residues 1 to 352)
  AUTHORS   Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
            Hart,G.W.
  TITLE     Murine elongation factor 1 alpha (EF-1 alpha) is
            posttranslationally modified by novel amide-linked
            ethanolamine-phosphoglycerol moieties. Addition of
            ethanolamine-phosphoglycerol to specific glutamic acid residues on
            EF-1 alpha
  JOURNAL   J. Biol. Chem. 264 (24), 14334-14341 (1989)
   PUBMED   
REFERENCE   10 (residues 1 to 352)
  AUTHORS   Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
  TITLE     Retropseudogenes constitute the major part of the human elongation
            factor 1 alpha gene family
  JOURNAL   Nucleic Acids Res. 18 (6), 1513-1516 (1990)
   PUBMED   
REFERENCE   8  (sites)
  AUTHORS   Oppermann,M., Mack,M., Proudfoot,A.E. and Olbrich,H.
  TITLE     Differential effects of CC chemokines on CC chemokine receptor 5
            (CCR5) phosphorylation and identification of phosphorylation sites
            on the CCR5 carboxyl terminus
  JOURNAL   J. Biol. Chem. 274 (13), 8875-8885 (1999)
   PUBMED   
REFERENCE   7  (sites)
  AUTHORS   Kraft,K., Olbrich,H., Majoul,I., Mack,M., Proudfoot,A. and
            Oppermann,M.
  TITLE     Characterization of sequence determinants within the
            carboxyl-terminal domain of chemokine receptor CCR5 that regulate
            signaling and receptor internalization
  JOURNAL   J. Biol. Chem. 276 (37), 34408-34418 (2001)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (sites)
  AUTHORS   Bannert,N., Craig,S., Farzan,M., Sogah,D., Santo,N.V., Choe,H. and
            Sodroski,J.
  TITLE     Sialylated O-glycans and sulfated tyrosines in the NH2-terminal
            domain of CC chemokine receptor 5 contribute to high affinity
            binding of chemokines
  JOURNAL   J. Exp. Med. 194 (11), 1661-1673 (2001)
   PUBMED   
LOCUS       NP_000570                352 aa            linear   PRI 16-NOV-2008
DEFINITION  chemokine (C-C motif) receptor 5 [Homo sapiens].
ACCESSION   NP_000570 XP_001125981
VERSION     NP_000570.1  GI:4502639
DBSOURCE    REFSEQ: accession