Mus musculus18424752
REFERENCE   2  (bases 1 to 3936)
  AUTHORS   Aihara,M., Lindsey,J.D. and Weinreb,R.N.
  TITLE     Effect on diurnal intraocular pressure variation of eliminating the
            alpha-2 adrenergic receptor subtypes in the mouse
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 49 (3), 929-933 (2008)
   PUBMED   18326714
REFERENCE   3  (bases 1 to 3936)
  AUTHORS   Muthig,V., Gilsbach,R., Haubold,M., Philipp,M., Ivacevic,T.,
            Gessler,M. and Hein,L.
  TITLE     Upregulation of soluble vascular endothelial growth factor receptor
            1 contributes to angiogenesis defects in the placenta of alpha
            2B-adrenoceptor deficient mice
  JOURNAL   Circ. Res. 101 (7), 682-691 (2007)
   PUBMED   1767367417636168
REFERENCE   5  (bases 1 to 3936)
  AUTHORS   Knaus,A., Zong,X., Beetz,N., Jahns,R., Lohse,M.J., Biel,M. and
            Hein,L.
  TITLE     Direct inhibition of cardiac hyperpolarization-activated cyclic
            nucleotide-gated pacemaker channels by clonidine
  JOURNAL   Circulation 115 (7), 872-880 (2007)
   PUBMED   17261653
REFERENCE   6  (bases 1 to 3936)
  AUTHORS   Link,R.E., Desai,K., Hein,L., Stevens,M.E., Chruscinski,A.,
            Bernstein,D., Barsh,G.S. and Kobilka,B.K.
  TITLE     Cardiovascular regulation in mice lacking alpha2-adrenergic
            receptor subtypes b and c
  JOURNAL   Science 273 (5276), 803-805 (1996)
   PUBMED   8670422
REFERENCE   7  (bases 1 to 3936)
  AUTHORS   Chang,N.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Chang,Y.H.,
            Chen,W.M. and Chang,A.C.
  TITLE     Assignment of two alpha 2 adrenoceptor subtype genes to murine
            chromosomes
  JOURNAL   Neurosci. Lett. 167 (1-2), 105-108 (1994)
   PUBMED   8177505
REFERENCE   8  (bases 1 to 3936)
  AUTHORS   Link,R.E., Kobilka,B.K. and Barsh,G.S.
  TITLE     Linkage mapping of alpha-2 adrenergic receptor genes to mouse
            chromosomes 2 and 5
  JOURNAL   Mamm. Genome 4 (11), 650-655 (1993)
   PUBMED   8281014
REFERENCE   9  (bases 1 to 3936)
  AUTHORS   Chen,W.M., Chang,A.C., Shie,B.J., Chang,Y.H. and Chang,N.C.
  TITLE     Molecular cloning and characterization of a mouse alpha 2C2
            adrenoceptor subtype gene
  JOURNAL   Biochim. Biophys. Acta 1171 (2), 219-223 (1992)
   PUBMED   13363961354956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731836.10.
            On Aug 9, 2006 this sequence version replaced gi:46575785.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no full-length high-quality transcript from the
            C57BL/6J reference strain was available. The extent of this
            transcript is supported by its existence in multiple strains.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3936              AL731836.10        11330-15265
FEATURES             Location/Qualifiers
     source          1..3936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.0 cM"
     gene            1..3936
                     /gene="Adra2b"
                     /gene_synonym="[a]2B"
                     /gene_synonym="Adra-2b"
                     /gene_synonym="alpha2B"
                     /gene_synonym="alpha2-C2"
                     /note="adrenergic receptor, alpha 2b"
                     /db_xref="GeneID:11552"
                     /db_xref="MGI:87935"
     exon            1..3936
                     /gene="Adra2b"
                     /gene_synonym="[a]2B"
                     /gene_synonym="Adra-2b"
                     /gene_synonym="alpha2B"
                     /gene_synonym="alpha2-C2"
                     /inference="alignment:Splign"
                     /number=1
     CDS             280..1641
                     /gene="Adra2b"
                     /gene_synonym="[a]2B"
                     /gene_synonym="Adra-2b"
                     /gene_synonym="alpha2B"
                     /gene_synonym="alpha2-C2"
                     /note="subtype alpha2-C2"
                     /codon_start=1
                     /product="adrenergic receptor, alpha 2b"
                     /protein_id="NP_033763.2CCDS16701.1"
                     /db_xref="GeneID:11552"
                     /db_xref="MGI:87935"
                     /translation="MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLT
                     SRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCT
                     SSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQR
                     PEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGS
                     GEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARAL
                     PPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQ
                     TSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFF
                     SYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQ
                     TGW"
     STS             1780..1945
                     /gene="Adra2b"
                     /gene_synonym="[a]2B"
                     /gene_synonym="Adra-2b"
                     /gene_synonym="alpha2B"
                     /gene_synonym="alpha2-C2"
                     /standard_name="M94583"
                     /db_xref="UniSTS:159024"
ORIGIN      
        1 cagctgtgcc gcacgacggc gcgactttcc tctggtcccg ggacggcagt gagacaactt
       61 ggaaaacttc tctggggcgg actgcaggga cgccgggcac cagtggcaga gaacgtaaga
      121 gagcgataga tggtcctggg tgtccccgga cctccggcca ggctacggtg ctccagagcc
      181 atctgcaccg cctgggggga cggcccccaa cagtagcgga gctagggtgg cgctttctcc
      241 tgcgtactgt gagtttggcc agcatctttc tctctggaca tgtccggccc cgccatggtc
      301 caccaggagc cctactcggt gcaggccacc gccgccatcg cgtcggccat cacctttctc
      361 atcctcttca ccattttcgg caatgcgctg gtaattctgg ctgtgttgac cagccgctct
      421 ctccgtgcac cacaaaacct cttcctggtg tcactggcag cagccgacat cctagtggct
      481 actcttatca tccctttctc tctggccaac gagctgctgg gctattggta cttctggcgt
      541 gcgtggtgcg aggtctacct ggcgctagac gtgctcttct gtacctcctc catcgtgcac
      601 ctgtgtgcca tcagtctgga cagatactgg gcagtgagcc gagcattgga gtacaactcc
      661 aagcgcactc cacgccgcat caaatgcatc atcctcaccg tgtggctcat tgcagccgtc
      721 atttctctac cgcccctcat ctacaagggc gaccagcgcc cagagcccca cgggctcccc
      781 cagtgtgagc tcaaccaaga agcctggtac atcttggctt ccagcatcgg atcttttttt
      841 gctccctgcc tcatcatgat tctcgtctac ctgcgaatct atgtaattgc caaacgcagc
      901 cactgcagag gtctcggagc taagaggggc tctggggagg gtgagtccaa gaagccccat
      961 ccggccgccg ggggagttcc agcctcggct aaagtgccca ccctggtctc tcctctatct
     1021 tctgtcggag aggctaatgg acaccccaag cctccaaggg agaaggagga gggggagacc
     1081 cctgaagatc ccgaagccag ggctttgcca cccaattggt ctgccctgcc cagatcagtc
     1141 caggaccaga agaaggggac tagtggggca actgcagaga agggagctga agaggatgaa
     1201 gaggaggtgg aagaatgtga accccaaaca ctgccagctt ctcctgcctc agtattcaac
     1261 ccacccttgc agcagcctca gacttcccgg gtgctggcca cgctacgtgg ccaggtgctt
     1321 ctgagcaaga atgtgggtgt ggccagtggg cagtggtggc gccgtcggac acagctgagc
     1381 cgagagaaga ggttcacctt tgtgctggcg gtggtcattg gtgtttttgt ggtctgttgg
     1441 tttcctttct tcttcagcta cagcctgggg gccatctgcc cacagcactg caaggtaccc
     1501 catggcctct tccagttctt cttctggatt ggctactgca acagctcttt gaatcctgtc
     1561 atctacacca tcttcaacca ggacttccgc cgtgcctttc gaaggatcct ttgccggcag
     1621 tggacccaga ctggctggtg agcctgcctg ctccgggcca gtgccaggca gggttagtgc
     1681 caggaccacc cggtggtagt ctgccacctc cgcagtctat gtgaccattt ccctggggcc
     1741 catttgcaga cctcatcctc agacacccct gaaggggaaa ggacaaatgt gctgttccca
     1801 ggggctcatt tgaaaccttc ccttgctgac tgtactgtgg gatacctctt ccctgctctc
     1861 tcttcaggaa gggtagcttg gaccttctcg aacgtggcca aggctgatta gaatacctcc
     1921 ctcccagcca cctgtaagcc aacaggcagg cttccctttc ctggagaccc cctgtgcctt
     1981 ggcaggccac ttgtggtggt tttctttctt tctcatcata ttcttctctt ctcttttatt
     2041 gttcatttca tttctttttt tttttttttt ttttttttga gacagggtct catgtagccc
     2101 agaccagtct cagacttgct atgcagcctg aggctgatct taagattctg cttacctctc
     2161 cagcatgaga agtaacaatg ctcaccacca tacctggttt acctgatgct ggggaatgaa
     2221 gtcggggctt caagcatgct agggaaacat ccaaccaacc gagttatatc cccagccttg
     2281 atcttcctca tgcctttcaa agagccggaa gcccatcttc tacatttccc aggaggacct
     2341 gatgctgaga aagaggacaa aaggaagagg attcagccgt gctgagcacc tgtggttctc
     2401 cttggctgtt gcggtggctg gttatggtct agtgctggtt gctgggtttt ttgtttgttt
     2461 tgttttgttt tgtttttaag ctttgtagcg tctttaaggc tagaagcatg ggttgttttc
     2521 tcactcagca tccctctggg aggcaagtgg gcacgtggat gcctcagtgg aatggtctgg
     2581 aatcctggcc tcgacctcac taaggtcctg atcactggca ttcaacctcg cagagagcag
     2641 ggtgacaatt gcctgccgcc tacttgcagc agggagatga aaggctttgc agagagcttt
     2701 gagctccatg ggggaaatgc gctagagagc cagcaaatgt gattatctgg tgatataaaa
     2761 atccctttcc tgtgtgttta ccactgtgag ccttcctgta gacttttgtt ctgtgcttgg
     2821 ggtgtgtgaa ttcctacccc aaactggaag tgggttgagg tgcacggagt cactctttca
     2881 aattccggaa tttctttgag aatgctttct tgtgcctgaa aaggtttgag ttattatgct
     2941 gttgtcagct tctccatctg ttacctgtaa cagagttttc agtggcttgg ccccaacccc
     3001 attaggggat aagctctttg tcattgagca ggcaaatcgt tttcctaagc taaaaatact
     3061 tacatcaagg aagcagtctg agatgagatc ctcaggtggg gtgctggggc tagaacaggc
     3121 agccaaggcc ctgtggactc ctgggatagc caccctctgt ggggtcccag acaactctct
     3181 gaaccccatg taacaccttt ggagacagaa ggagacccca gctcagaagg atgtctcatt
     3241 agctgttacg aaccctcatg gcgatacagc tgtgcactag ggtgtctcta cctcctggtt
     3301 gtctccccga cttagaaatt gctccccaga gtgactgggg atgcatctgg gccttcccca
     3361 caagcagcct gacttcagct ttgggcaata gacctcttag cctcagggaa ggggtagatt
     3421 gagccatgca ggctacaagc tacacaggct attagcccag ggtgggttta tcagattttg
     3481 aaggtgctaa gggagttttc tcgggtaaag acaaagatgg gtcctaaatt gaattcctct
     3541 tggagaggat gaatagcttg gtccttggtt ggttgctgtt tcgaggctag gacattgatt
     3601 tggggtgtgg ctgaggggtt ggtttggttt tttgtttttg ttttttgttt gtttgtttgt
     3661 ttttgagaca gggtttctct gtgtgaccct ggttactctg gaactcactc tttagaccag
     3721 gctgcccttg aactcacaaa gatttgcctg cctctgcttc ccgagtgctg ggatcaaagg
     3781 cgtacactac cactgcctgg cagcagggca gatttgtaac catctgctgg ctgatcttgt
     3841 gtatgcttca tgggacccaa gccccctgtt gtgacatata ggtgtttcta agactctgag
     3901 ctattttatc aataaaggct attttttaat aagcaa
//
"
                     /db_xref="GI:46575786"
                     /db_xref="CCDS:
REFERENCE   10 (bases 1 to 3936)
  AUTHORS   Chruscinski,A.J., Link,R.E., Daunt,D.A., Barsh,G.S. and
            Kobilka,B.K.
  TITLE     Cloning and expression of the mouse homolog of the human alpha 2-C2
            adrenergic receptor
  JOURNAL   Biochem. Biophys. Res. Commun. 186 (3), 1280-1287 (1992)
   PUBMED   
  REMARK    GeneRIF: alpha2B adrenoceptor deficient mice develop a defect in
            fetal and maternal vessel formation in the placenta.
REFERENCE   4  (bases 1 to 3936)
  AUTHORS   Cikos,S., Rehak,P., Czikkova,S., Vesela,J. and Koppel,J.
  TITLE     Expression of adrenergic receptors in mouse preimplantation embryos
            and ovulated oocytes
  JOURNAL   Reproduction 133 (6), 1139-1147 (2007)
   PUBMED   
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Mus.
REFERENCE   1  (bases 1 to 3936)
  AUTHORS   Takedachi,M., Qu,D., Ebisuno,Y., Oohara,H., Joachims,M.L.,
            McGee,S.T., Maeda,E., McEver,R.P., Tanaka,T., Miyasaka,M.,
            Murakami,S., Krahn,T., Blackburn,M.R. and Thompson,L.F.
  TITLE     CD73-generated adenosine restricts lymphocyte migration into
            draining lymph nodes
  JOURNAL   J. Immunol. 180 (9), 6288-6296 (2008)
   PUBMED   
LOCUS       NM_009633               3936 bp    mRNA    linear   ROD 29-JUN-2008
DEFINITION  Mus musculus adrenergic receptor, alpha 2b (Adra2b), mRNA.
ACCESSION   NM_009633
VERSION     NM_009633.3  GI:111548655
KEYWORDS    .
SOURCE      Mus musculus (house mouse)
  ORGANISM