Homo sapiens18854756
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Tikhonoff,V., Hasenkamp,S., Kuznetsova,T., Thijs,L., Jin,Y.,
            Richart,T., Zhang,H., Brand-Herrmann,S.M., Brand,E., Casiglia,E.
            and Staessen,J.A.
  TITLE     Blood pressure and metabolic phenotypes in relation to the ADRB1
            Arg389Gly and ADRA2B I/D polymorphisms in a White population
  JOURNAL   J Hum Hypertens (2008) In press
   PUBMED   18596718
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Huhtinen,A. and Scheinin,M.
  TITLE     Expression and characterization of the human alpha 2B-adrenoceptor
            in a vascular smooth muscle cell line
  JOURNAL   Eur. J. Pharmacol. 587 (1-3), 48-56 (2008)
   PUBMED   18456256
  REMARK    GeneRIF: A vascular smooth muscle cell line stably expressing the
            human alpha 2B-adrenoceptor was generated by transfection of rat
            cells
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Wray,D.W., Raven,P.B. and Sander,M.
  TITLE     Diminished baroreflex-induced vasoconstriction following alpha-2
            adrenergic receptor blockade in humans
  JOURNAL   Auton Neurosci 138 (1-2), 114-117 (2008)
   PUBMED   18054844
  REMARK    GeneRIF: These data indicate that alpha-2 adrenergic receptors
            contribute significantly to CBR-induced vasoconstriction in the
            human leg under resting conditions.
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Vasudevan,R., Ismail,P., Stanslas,J., Shamsudin,N. and Ali,A.B.
  TITLE     Association of insertion/deletion polymorphism of
            alpha-adrenoceptor gene in essential hypertension with or without
            type 2 diabetes mellitus in Malaysian subjects
  JOURNAL   Int. J. Biol. Sci. 4 (6), 362-367 (2008)
   PUBMED   18953403
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Weinshank,R.L., Zgombick,J.M., Macchi,M., Adham,N., Lichtblau,H.,
            Branchek,T.A. and Hartig,P.R.
  TITLE     Cloning, expression, and pharmacological characterization of a
            human alpha 2B-adrenergic receptor
  JOURNAL   Mol. Pharmacol. 38 (5), 681-688 (1990)
   PUBMED   2172775
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Chang,A.C., Ho,T.F. and Chang,N.C.
  TITLE     In vitro amplification by polymerase chain reaction of a partial
            gene encoding the third subtype of alpha-2 adrenergic receptor in
            humans
  JOURNAL   Biochem. Biophys. Res. Commun. 172 (2), 817-823 (1990)
   PUBMED   2173582
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   McClue,S.J. and Milligan,G.
  TITLE     The alpha 2B adrenergic receptor of undifferentiated neuroblastoma
            x glioma hybrid NG108-15 cells, interacts directly with the guanine
            nucleotide binding protein, Gi2
  JOURNAL   FEBS Lett. 269 (2), 430-434 (1990)
   PUBMED   216943421642212842764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY548167.1, CV806541.1,
            AC092603.2 and AA887330.1.
            On Jul 7, 2006 this sequence version replaced gi:55743081.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. They include 3 highly
            homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
            have a critical role in regulating neurotransmitter release from
            sympathetic nerves and from adrenergic neurons in the central
            nervous system. This gene encodes the alpha2B subtype, which was
            observed to associate with eIF-2B, a guanine nucleotide exchange
            protein that functions in regulation of translation. A polymorphic
            variant of the alpha2B subtype, which lacks 3 glutamic acids from a
            glutamic acid repeat element, was identified to have decreased G
            protein-coupled receptor kinase-mediated phosphorylation and
            desensitization; this polymorphic form is also associated with
            reduced basal metabolic rate in obese subjects and may therefore
            contribute to the pathogenesis of obesity. This gene contains no
            introns in either its coding or untranslated sequences. [provided
            by RefSeq].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1181              AY548167.1         1-1181
            1182-1193           CV806541.1         723-734
            1194-3232           AC092603.2         12108-14146         c
            3233-3288           AA887330.1         1-56                c
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13-q13"
     gene            1..3288
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /note="adrenergic, alpha-2B-, receptor"
                     /db_xref="GeneID:151"
                     /db_xref="HGNC:282"
                     /db_xref="HPRD:00086"
                     /db_xref="MIM:104260"
     exon            1..3275
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /inference="alignment:Splign"
                     /number=1
     STS             1..1627
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /db_xref="UniSTS:483802"
     STS             1..1403
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /db_xref="UniSTS:481696"
     CDS             1..1353
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /note="alpha-2-adrenergic receptor-like 1; G-protein
                     coupled receptor; adrenergic receptor alpha 2B; ADRA2B
                     adrenergic, alpha-2B-, receptor"
                     /codon_start=1
                     /product="alpha-2B-adrenergic receptor"
                     /protein_id="NP_000673.2151"
                     /db_xref="HGNC:282"
                     /db_xref="HPRD:00086"
                     /db_xref="MIM:104260"
                     /translation="MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLR
                     APQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVH
                     LCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRG
                     RPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGES
                     KQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAA
                     LPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR
                     VLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYS
                     LGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW"
     misc_feature    880..933
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /note="Region: Asp/Glu-rich domain"
     STS             557..1477
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /standard_name="ADRA2B__4260"
                     /db_xref="UniSTS:462717"
     STS             1397..1585
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
                     /standard_name="RH80277"
                     /db_xref="UniSTS:89742"
     polyA_signal    3253..3258
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
     polyA_site      3275
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1"
                     /gene_synonym="ADRARL1"
                     /gene_synonym="ADRA2RL1"
                     /gene_synonym="ALPHA2BAR"
ORIGIN      
        1 atggaccacc aggaccccta ctccgtgcag gccacagcgg ccatagcggc ggccatcacc
       61 ttcctcattc tctttaccat cttcggcaac gctctggtca tcctggctgt gttgaccagc
      121 cgctcgctgc gcgcccctca gaacctgttc ctggtgtcgc tggccgccgc cgacatcctg
      181 gtggccacgc tcatcatccc tttctcgctg gccaacgagc tgctgggcta ctggtacttc
      241 cggcgcacgt ggtgcgaggt gtacctggcg ctcgacgtgc tcttctgcac ctcgtccatc
      301 gtgcacctgt gcgccatcag cctggaccgc tactgggccg tgagccgcgc gctggagtac
      361 aactccaagc gcaccccgcg ccgcatcaag tgcatcatcc tcactgtgtg gctcatcgcc
      421 gccgtcatct cgctgccgcc cctcatctac aagggcgacc agggccccca gccgcgcggg
      481 cgcccccagt gcaagctcaa ccaggaggcc tggtacatcc tggcctccag catcggatct
      541 ttctttgctc cttgcctcat catgatcctt gtctacctgc gcatctacct gatcgccaaa
      601 cgcagcaacc gcagaggtcc cagggccaag ggggggcctg ggcagggtga gtccaagcag
      661 ccccgacccg accatggtgg ggctttggcc tcagccaaac tgccagccct ggcctctgtg
      721 gcttctgcca gagaggtcaa cggacactcg aagtccactg gggagaagga ggagggggag
      781 acccctgaag atactgggac ccgggccttg ccacccagtt gggctgccct tcccaactca
      841 ggccagggcc agaaggaggg tgtttgtggg gcatctccag aggatgaagc tgaagaggag
      901 gaagaggagg aggaggagga ggaagagtgt gaaccccagg cagtgccagt gtctccggcc
      961 tcagcttgca gccccccgct gcagcagcca cagggctccc gggtgctggc caccctacgt
     1021 ggccaggtgc tcctgggcag gggcgtgggt gctataggtg ggcagtggtg gcgtcgacgg
     1081 gcgcagctga cccgggagaa gcgcttcacc ttcgtgctgg ctgtggtcat tggcgttttt
     1141 gtgctctgct ggttcccctt cttcttcagc tacagcctgg gagccatctg cccgaagcac
     1201 tgcaaggtgc cccatggcct cttccagttc ttcttctgga tcggctactg caacagctca
     1261 ctgaaccctg ttatctacac catcttcaac caggacttcc gccgtgcctt ccggaggatc
     1321 ctgtgccgcc cgtggaccca gacggcctgg tgagcccgcc tgcgctgccc ctgtggggtt
     1381 ggtgcggtgg cgccggggtc accctgcttc ttgccctgct gtgtgtggct gcctcccctg
     1441 ggctttctgc tccctgccca gatcctgtag gcctcatctt aggaacccct tgggaggggt
     1501 gggcaggggg gctgctagca agggtcccag tgaagcttcc ccttgccggc ttagctgtgg
     1561 gggacccctt ctccaccctc tccctgagca caggccgatg gaggtggttc aaatcctctg
     1621 gaacatagcc aagaccagga gaagagagag cactttcttc ccagagcccc atgctctcca
     1681 gaccaatgtc tgggcttccc tttcttgagg accttgtgtt cctggcaggt cacttgcttg
     1741 tggtgttttc gtttcttttt catctccccc ccacccacaa agagcacgga gccagccttc
     1801 cacttttccc agtggggcct gctgctgagg gggaggaaga aacgaagact gatcacccac
     1861 gctaggcact cgcggtccct ggcaggcgct gggatggggg cttatggggt ggcatcgtct
     1921 ctgggccctc ctttccccct ttgcctgttt tcggatctgt ggttcctttg aaagccagaa
     1981 caatggatcg gcttccttac ccagcacccc tccggtaggt gggtggccac gtggatgcct
     2041 cgctggggcg gtcttggagg cctggtctct gcctcgacgg gagatccccg atcactggca
     2101 ttcaccccct gcaaaaatcg gggcgacaat agctcactgc ctacttgctg cagggagatg
     2161 aaaggctttg cagaaagctt tgagctctgt gggggaacac actagagaac caaaaatgtg
     2221 attatatggt gatataaaaa tccctttcct ctgtgtttac caccacctgt cttcctgtag
     2281 acttttgttc tgtccctggg gtgtgtgaat tcctaccccg aactggaagc cgggagtggc
     2341 agacagaatc actatttcaa gttaaaggat ctctttgaga atgtgttctt ctggctgcaa
     2401 aggtctgagt tattacgcta catgacaacg tttcgacatt tcaccggcaa caccaagagg
     2461 gtttttagtg gcttgggtct ccccagtggg ggataagtct tttgtcatca aggaggcaaa
     2521 ttgtctcccc aagacagctc aaaatatcca cacctcggca acagtctaag atgagagcct
     2581 gtgacaggtg gcagcgcccc caggtggggt actggcatca gagcctggtg cgcccctagg
     2641 ggagcctccc actggagtgc ccggccaggt ctccaagccc caaatgagtc cttgtgaacc
     2701 acaactgatc cccccaggtg ggtgcttgtg gactgcctcg gacccagcca cgctgctccc
     2761 cgcaatgctg atggggctgt gcattgagga cccctgcttc ctggttctca gtcccacccc
     2821 aaaacctggc acccagaaca gttggaagtg tggaaaggag gtttatcggc cttcccttgg
     2881 agagggcctg gcttcaacat tgggccagta ggcatcttag cttggcaggt gtcgggggaa
     2941 tgggccagat ggacctgcta gatttggaag ggcaccgagg gagttttctg ggtgtagaga
     3001 gaatggaggg gaccaaaaag agtccttcct ggggtgtggg aggcttccca gcttggtcct
     3061 cagtgggttg ttgaggccag agtatcgccc tgggatgtgg tggggagctg ggccaggaga
     3121 gggactgact gtgaccctct gctggccggt cttgtgtgcg ccccatggga cccccagtgt
     3181 tcttgcctgt gacctcttat tgcgacatgc aggtggtgtt tttttttttt ttaaactctg
     3241 agctatttta tcaataaagg atattttgta ataagaaaaa aaaaaaaa
//
"
                     /db_xref="GI:33598960"
                     /db_xref="GeneID:
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Regan,J.W., Kobilka,T.S., Yang-Feng,T.L., Caron,M.G.,
            Lefkowitz,R.J. and Kobilka,B.K.
  TITLE     Cloning and expression of a human kidney cDNA for an alpha
            2-adrenergic receptor subtype
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (17), 6301-6305 (1988)
   PUBMED   
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Lomasney,J.W., Lorenz,W., Allen,L.F., King,K., Regan,J.W.,
            Yang-Feng,T.L., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Expansion of the alpha 2-adrenergic receptor family: cloning and
            characterization of a human alpha 2-adrenergic receptor subtype,
            the gene for which is located on chromosome 2
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5094-5098 (1990)
   PUBMED   
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Li,L.H., Li,Y., Wen,Y. and Wang,J.G.
  TITLE     Anthropometric and metabolic phenotypes in relation to the ADRA2B
            deletion/insertion polymorphism in Chinese population
  JOURNAL   J. Hypertens. 26 (11), 2161-2167 (2008)
   PUBMED   
LOCUS       NM_000682               3288 bp    mRNA    linear   PRI 16-NOV-2008
DEFINITION  Homo sapiens adrenergic, alpha-2B-, receptor (ADRA2B), mRNA.
ACCESSION   NM_000682
VERSION     NM_000682.5  GI:110227861
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM