Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Wakeno,M., Kato,M., Okugawa,G., Fukuda,T., Hosoi,Y., Takekita,Y.,
            Yamashita,M., Nonen,S., Azuma,J. and Kinoshita,T.
  TITLE     The alpha 2A-adrenergic receptor gene polymorphism modifies
            antidepressant responses to milnacipran
  JOURNAL   J Clin Psychopharmacol 28 (5), 518-524 (2008)
   PUBMED   1879464618725220
  REMARK    GeneRIF: Clinical trial of gene-disease association, gene-gene
            interaction, gene-environment interaction, and pharmacogenomic /
            toxicogenomic. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Yabe,M., Matsubara,Y., Takahashi,S., Ishihara,H., Shibano,T.,
            Watanabe,G., Murata,M. and Ikeda,Y.
  TITLE     Alpha 2A adrenergic receptor polymorphism is associated with plasma
            von Willebrand factor levels in a general population
  JOURNAL   Blood Coagul. Fibrinolysis 19 (5), 395-399 (2008)
   PUBMED   18600088
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Tanabe,M.
  TITLE     [Imidazoline receptor]
  JOURNAL   Nippon Yakurigaku Zasshi 131 (6), 478-480 (2008)
   PUBMED   18561481
  REMARK    GeneRIF: shows strong affinity to idazoxan and excists in MAO of
            mitochondria which has imidazoline-ligand binding sites in its
            molecule.
            Review article
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Karahalil,B., Coskun,E. and Emerce,E.
  TITLE     ADRA2A polymorphism and smoking in a Turkish population
  JOURNAL   Toxicol Ind Health 24 (3), 171-176 (2008)
   PUBMED   188426951385431
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Perala,M., Hirvonen,H., Kalimo,H., Ala-Uotila,S., Regan,J.W.,
            Akerman,K.E. and Scheinin,M.
  TITLE     Differential expression of two alpha 2-adrenergic receptor subtype
            mRNAs in human tissues
  JOURNAL   Brain Res. Mol. Brain Res. 16 (1-2), 57-63 (1992)
   PUBMED   1334200
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Surprenant,A., Horstman,D.A., Akbarali,H. and Limbird,L.E.
  TITLE     A point mutation of the alpha 2-adrenoceptor that blocks coupling
            to potassium but not calcium currents
  JOURNAL   Science 257 (5072), 977-980 (1992)
   PUBMED   13543941678390
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Wang,C.D., Buck,M.A. and Fraser,C.M.
  TITLE     Site-directed mutagenesis of alpha 2A-adrenergic receptors:
            identification of amino acids involved in ligand binding and
            receptor activation by agonists
  JOURNAL   Mol. Pharmacol. 40 (2), 168-179 (1991)
   PUBMED   1678850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158163.11, AF284095.1 and
            BM682651.1.
            On Jul 22, 2008 this sequence version replaced gi:15718669FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24-q26"
     gene            1..3889
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /note="adrenergic, alpha-2A-, receptor"
                     /db_xref="GeneID:150"
                     /db_xref="HGNC:281"
                     /db_xref="HPRD:00078"
                     /db_xref="MIM:104210"
     exon            1..3876
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /inference="alignment:Splign"
                     /number=1
     STS             609..833
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /standard_name="STS-AA040321"
                     /db_xref="UniSTS:40025"
     CDS             966..2363
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /note="alpha-2AAR subtype C10; alpha2A adrenergic
                     receptor; alpha-2-adrenergic receptor, platelet type;
                     alpha-2A adrenoceptor"
                     /codon_start=1
                     /product="alpha-2A-adrenergic receptor"
                     /protein_id="NP_000672.3CCDS7569.1"
                     /db_xref="GeneID:150"
                     /db_xref="HGNC:281"
                     /db_xref="HPRD:00078"
                     /db_xref="MIM:104210"
                     /translation="MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYS
                     LQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVI
                     PFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKR
                     TPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIG
                     SFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGP
                     GGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKG
                     KARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLA
                     VVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR
                     AFKKILCRGDRKRIV"
     misc_feature    1011..1013
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /note="Region: alternative translation initiation codon"
     STS             3464..3594
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /standard_name="RH93859"
                     /db_xref="UniSTS:87259"
     STS             3599..3717
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
                     /standard_name="D10S1861"
                     /db_xref="UniSTS:39286"
     polyA_signal    3732..3737
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
     polyA_site      3754
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
     polyA_signal    3760..3765
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
     polyA_site      3781
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
     polyA_signal    3853..3858
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
     polyA_site      3876
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2"
                     /gene_synonym="ADRAR"
                     /gene_synonym="ZNF32"
                     /gene_synonym="ADRA2R"
                     /gene_synonym="ALPHA2AAR"
ORIGIN      
        1 cagcagcagc tccagctcgg tgcagaagcc cagcagccgg cgtgccgccg cccggccact
       61 ccagcgcctt cttccccgcc ttgcgctcct gccccaactc gcgctgtcgt cggaccccgg
      121 cccatccagc agcgctcggc gcccaccagg cggacgccca ggagaacccc tgcctccgtc
      181 gcggctcctg gagagctgat cgttcacctg ccccggcccg cctgaggacg ggggtgcctt
      241 catgcggccc ccacactcct caccccgccg ccgccgccgt cccggagctc cgcacagtgt
      301 gccccagccc cagcagggcg cacaactttg gaagtctcgc ggcgctccga gaggcggcag
      361 agtccgcgcc ccagccccgg gccgggccgg gccagaaccg cagcgtctgg gggaagccag
      421 agagtcggta atcgcttcgg ggatgtaagg cgacagacat aggacccccg agctcgcatc
      481 agcacccttc ggctgcctcc cggggtgggg gcgggccccg cacacggtaa gacctcttgc
      541 tttcgctcag gctcaagatt caagatacag atattgatat gtatatatat atttaatttc
      601 ctgtcatcct tccaagttat caggccaccg atgatttttg ttctcccttc ttgaagaata
      661 aatctctctt tacccatcgg ctctccctac tctctcccgc cgcttagaaa taaaacttgg
      721 ctgtattagg agctcggagc aagaaggcgc ccaccgagag cgtctgaagc gcgagccagg
      781 cgcagttcgc gggacccggg ccatgggccg ctagcggtcc tccagttcgg gcccggcctc
      841 cctgcggccc cctccctatg tgagccgcag ccaggcgagc ggggcgccgg aggaagagga
      901 ggacccacgg gcgccgggcc ggaaggcagc tggcagcagg cccaggccag cgggcgcccg
      961 cgttcatgtt ccgccaggag cagccgttgg ccgagggcag ctttgcgccc atgggctccc
     1021 tgcagccgga cgcgggcaac gcgagctgga acgggaccga ggcgccgggg ggcggcgccc
     1081 gggccacccc ttactccctg caggtgacgc tgacgctggt gtgcctggcc ggcctgctca
     1141 tgctgctcac cgtgttcggc aacgtgctcg tcatcatcgc cgtgttcacg agccgcgcgc
     1201 tcaaggcgcc ccaaaacctc ttcctggtgt ctctggcctc ggccgacatc ctggtggcca
     1261 cgctcgtcat ccctttctcg ctggccaacg aggtcatggg ctactggtac ttcggcaagg
     1321 cttggtgcga gatctacctg gcgctcgacg tgctcttctg cacgtcgtcc atcgtgcacc
     1381 tgtgcgccat cagcctggac cgctactggt ccatcacaca ggccatcgag tacaacctga
     1441 agcgcacgcc gcgccgcatc aaggccatca tcatcaccgt gtgggtcatc tcggccgtca
     1501 tctccttccc gccgctcatc tccatcgaga agaagggcgg cggcggcggc ccgcagccgg
     1561 ccgagccgcg ctgcgagatc aacgaccaga agtggtacgt catctcgtcg tgcatcggct
     1621 ccttcttcgc tccctgcctc atcatgatcc tggtctacgt gcgcatctac cagatcgcca
     1681 agcgtcgcac ccgcgtgcca cccagccgcc ggggtccgga cgccgtcgcc gcgccgccgg
     1741 ggggcaccga gcgcaggccc aacggtctgg gccccgagcg cagcgcgggc ccggggggcg
     1801 cagaggccga accgctgccc acccagctca acggcgcccc tggcgagccc gcgccggccg
     1861 ggccgcgcga caccgacgcg ctggacctgg aggagagctc gtcttccgac cacgccgagc
     1921 ggcctccagg gccccgcaga cccgagcgcg gtccccgggg caaaggcaag gcccgagcga
     1981 gccaggtgaa gccgggcgac agcctgccgc ggcgcgggcc gggggcgacg gggatcggga
     2041 cgccggctgc agggccgggg gaggagcgcg tcggggctgc caaggcgtcg cgctggcgcg
     2101 ggcggcagaa ccgcgagaag cgcttcacgt tcgtgctggc cgtggtcatc ggagtgttcg
     2161 tggtgtgctg gttccccttc ttcttcacct acacgctcac ggccgtcggg tgctccgtgc
     2221 cacgcacgct cttcaaattc ttcttctggt tcggctactg caacagctcg ttgaacccgg
     2281 tcatctacac catcttcaac cacgatttcc gccgcgcctt caagaagatc ctctgtcggg
     2341 gggacaggaa gcggatcgtg tgaggtttcc gctggcgccc gcgtagactc acgctgactg
     2401 caggcagcgg ggggcatcga ggggtgctta gccccagggc actcagaaac ccgggcgctg
     2461 cctgctctgc gtttcctcgt ctggggtggc tctgcagcct cctgcgggcg ggcgtctgct
     2521 gctcctacaa gggaagcttc ttgctgccag gcccacacat ccccagttgt tggtttggcc
     2581 actcttgacc tggagccatc ttcctagtgg gccaccccta atcactattg cttcctaaag
     2641 gtattttcac cctcttcgcc tggtacagcc ctcacagctc ttcagagcaa gcactggact
     2701 acaagggcat ggctcacaaa aggttaatgg atgggggtta cctagccctg gctaattccc
     2761 cttccattcc caactctctc tctcttttta aagaaaaatg ctaagggcag ccctgcctgc
     2821 cctccccatc ccccgctgta aatatacact atttttgata gcacacatgg ggcccccata
     2881 tctcttggcc ttggttttga tgttgaaatc ctggccttgg gagagatgcc ttccaggcag
     2941 acacagctgt ctggttcagg ccaagcccct ttgcaatgca agccctttct ggtgttatga
     3001 agtccctcta tgtcgtcgtt ttcaccagca actggtgact gtcccttcga cacggacctg
     3061 ctttgagatt tcctgacagg gaaaagattt ctgtccattt ttttcctgtg cctaacagca
     3121 taattgcctt ttcctatgta aatattatga tggtggatca agacataagt aaatgagcct
     3181 ttctgcctca catcagccct gtgtataaag ccattattct ctgatgcact gtttgcccca
     3241 gtaactcact ttaaaacctc tctttccagt gttccctctc tccctccagg gccactgctt
     3301 gaagaagaat atgtatgttt ctatcttgta tgtctgtgtg cccctcctgc cccgaaagtg
     3361 ctgactatgg ggaaatcttt tagctgctgt ttttagactc caaggagtgg aaattatgtg
     3421 gaagaagcaa acctgataca atttgcccaa ggtaaacagt ttgaaaagac aaatgggcct
     3481 gccaaactgt acagtttctt ccccaagagc tgttaggtat caaaatgttg tcctttcccc
     3541 cctccgtgct tttctggttg agatcatgtc attgatgaac tgccaaagtc aggggaggag
     3601 ggcagagact ttgtgtttac atctgcattt ctacatgttt tagacagaga caatttaagg
     3661 cctgcactct tatttcacta aagaaaaact aatgtcagca catgttgcta atgacagtgg
     3721 attttttttt aaataaaaaa gtttacagat caaatgtgaa ataaatatga atggagtggt
     3781 cctcttgtct gttatctgag ttttcaaaag ctttaagact ctgggaacat ctgattttat
     3841 ggatttttta aaaataaaaa atgtacatta taaaaaaaaa aaaaaaaaa
//
"
                     /db_xref="GI:194353970"
                     /db_xref="CCDS:.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. They include 3 highly
            homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
            have a critical role in regulating neurotransmitter release from
            sympathetic nerves and from adrenergic neurons in the central
            nervous system. Studies in mouse revealed that both the alpha2A and
            alpha2C subtypes were required for normal presynaptic control of
            transmitter release from sympathetic nerves in the heart and from
            central noradrenergic neurons; the alpha2A subtype inhibited
            transmitter release at high stimulation frequencies, whereas the
            alpha2C subtype modulated neurotransmission at lower levels of
            nerve activity. This gene encodes alpha2A subtype and it contains
            no introns in either its coding or untranslated sequences.
            [provided by RefSeq].
            
            Sequence Note: The 5'-most in-frame translation initiation codon is
            selected for this RefSeq based on good conservation across
            mammalian species. A possible downstream start codon would result
            in a protein that is 15 aa shorter at the N-terminus. The
            literature, including PMIDs:2823383, 2568356, 1354394 and 1678390,
            assumes the use of the downstream start codon based on initial
            cloning reports, but there is no experimental evidence indicating
            which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL158163.11        194560-194690
            132-283             AF284095.1         1-152
            284-300             AL158163.11        194843-194859
            301-2789            AF284095.1         170-2658
            2790-2790           AL158163.11        197349-197349
            2791-3781           AF284095.1         2660-3650
            3782-3889           BM682651.1         1-108               c

REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Suryanarayana,S., Daunt,D.A., Von Zastrow,M. and Kobilka,B.K.
  TITLE     A point mutation in the seventh hydrophobic domain of the alpha 2
            adrenergic receptor increases its affinity for a family of beta
            receptor antagonists
  JOURNAL   J. Biol. Chem. 266 (23), 15488-15492 (1991)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Handy,D.E. and Gavras,H.
  TITLE     Promoter region of the human alpha 2A adrenergic receptor gene
  JOURNAL   J. Biol. Chem. 267 (33), 24017-24022 (1992)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Grudell,A.B., Sweetser,S., Camilleri,M., Eckert,D.J.,
            Vazquez-Roque,M.I., Carlson,P.J., Burton,D.D., Braddock,A.E.,
            Clark,M.M., Graszer,K.M., Kalsy,S.A. and Zinsmeister,A.R.
  TITLE     A controlled pharmacogenetic trial of sibutramine on weight loss
            and body composition in obese or overweight adults
  JOURNAL   Gastroenterology 135 (4), 1142-1154 (2008)
   PUBMED   
LOCUS       NM_000681               3889 bp    mRNA    linear   PRI 16-NOV-2008
DEFINITION  Homo sapiens adrenergic, alpha-2A-, receptor (ADRA2A), mRNA.
ACCESSION   NM_000681
VERSION     NM_000681.3  GI:194353969
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM