Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3686)
  AUTHORS   Singh,K.K., Hughes,M.D., Chen,J., Phiri,K., Rousseau,C., Kuhn,L.,
            Coutsoudis,A., Jackson,J.B., Guay,L.A., Musoke,P., Mmiro,F.,
            Semba,R.D. and Spector,S.A.
  TITLE     Associations of chemokine receptor polymorphisms With HIV-1
            mother-to-child transmission in sub-Saharan Africa: possible
            modulation of genetic effects by antiretrovirals
  JOURNAL   J. Acquir. Immune Defic. Syndr. 49 (3), 259-265 (2008)
   PUBMED   18845960
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   2  (bases 1 to 3686)
  AUTHORS   Reiche,E.M., Ehara Watanabe,M.A., Bonametti,A.M., Morimoto,H.K.,
            Akira Morimoto,A., Wiechmann,S.L., Matsuo,T., Carvalho De
            Oliveira,J. and Vissoci Reiche,F.
  TITLE     Frequency of CCR5-Delta32 deletion in human immunodeficiency virus
            type 1 (HIV-1) in healthy blood donors, HIV-1-exposed seronegative
            and HIV-1-seropositive individuals of southern Brazilian population
  JOURNAL   Int. J. Mol. Med. 22 (5), 669-675 (2008)
   PUBMED   18949389
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3686)
  AUTHORS   Wang,Y., Wang,X., Peng,J., Chen,L., Cheng,J., Nie,S., Feng,T.,
            Zhao,G., Zhao,J. and Shi,X.
  TITLE     SDF1-3'A Gene Mutation Is Correlated with Increased Susceptibility
            to HIV Type 1 Infection by Sexual Transmission in Han Chinese
  JOURNAL   AIDS Res. Hum. Retroviruses (2008) In press
   PUBMED   18928397
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3686)
  AUTHORS   Rigato,P.O., Hong,M.A., Casseb,J., Ueda,M., de Castro,I., Benard,G.
            and Duarte,A.J.
  TITLE     Better CD4+ T cell recovery in Brazilian HIV-infected individuals
            under HAART due to cumulative carriage of SDF-1-3'A, CCR2-V64I,
            CCR5-D32 and CCR5-promoter 59029A/G polymorphisms
  JOURNAL   Curr. HIV Res. 6 (5), 466-473 (2008)
   PUBMED   18855658
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3686)
  AUTHORS   Ganczak,M., Bohatyrewicz,A., Szych,Z. and Bialecki,P.
  TITLE     [Markers of hepatitis B, C and HIV among orthopedic patients and
            staff at a Polish university hospital]
  JOURNAL   Chir Narzadow Ruchu Ortop Pol 73 (2), 83-88 (2008)
   PUBMED   188469992183196256946725643923346208
REFERENCE   10 (bases 1 to 3686)
  AUTHORS   Brands,J.H., Maassen,J.A., van Hemert,F.J., Amons,R. and Moller,W.
  TITLE     The primary structure of the alpha subunit of human elongation
            factor 1. Structural aspects of guanine-nucleotide-binding sites
  JOURNAL   Eur. J. Biochem. 155 (1), 167-171 (1986)
   PUBMED   3512269
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098613.2, DA818906.1,
            U54994.1 and BC038398.1.
            On Jul 27, 2007 this sequence version replaced gi:118572593.
            
            Summary: This gene encodes a member of the beta chemokine receptor
            family, which is predicted to be a seven transmembrane protein
            similar to G protein-coupled receptors. This protein is expressed
            by T cells and macrophages, and is known to be an important
            co-receptor for macrophage-tropic virus, including HIV, to enter
            host cells. Defective alleles of this gene have been associated
            with the HIV infection resistance. The ligands of this receptor
            include monocyte chemoattractant protein 2 (MCP-2), macrophage
            inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory
            protein 1 beta (MIP-1 beta) and regulated on activation normal T
            expressed and secreted protein (RANTES). Expression of this gene
            was also detected in a promyeloblastic cell line, suggesting that
            this protein may play a role in granulocyte lineage proliferation
            and differentiation. This gene is located at the chemokine receptor
            gene cluster region. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq].
            
            Transcript Variant: This variant (A) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by published experimental evidence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC098613.2         26671-26727
            58-211              AC098613.2         27229-27382
            212-767             DA818906.1         1-556
            768-2433            U54994.1           465-2130
            2434-3134           BC038398.1         2120-2820
            3135-3275           U54994.1           2832-2972
            3276-3686           BC038398.1         2962-3372
FEATURES             Location/Qualifiers
     source          1..3686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3686
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /note="chemokine (C-C motif) receptor 5"
                     /db_xref="GeneID:1234"
                     /db_xref="HGNC:1606"
                     /db_xref="HPRD:03223"
                     /db_xref="MIM:601373"
     exon            1..57
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /inference="alignment:Splign"
                     /number=1
     exon            58..346
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /inference="alignment:Splign"
                     /number=2a
     exon            347..3661
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /inference="alignment:Splign"
                     /number=3
     CDS             358..1416
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /note="chemr13; chemokine (C-C) receptor 5; C-C chemokine
                     receptor 5; chemokine receptor CCR5; CCR5 chemokine
                     receptor; C-C chemokine receptor type 5"
                     /codon_start=1
                     /product="chemokine (C-C motif) receptor 5"
                     /protein_id="NP_000570.1"
                     /db_xref="GI:4502639"
                     /db_xref="CCDS:CCDS2739.1"
                     /db_xref="GeneID:1234"
                     /db_xref="HGNC:1606"
                     /db_xref="HPRD:03223"
                     /db_xref="MIM:601373"
                     /translation="MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFG
                     FVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQ
                     LLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFAS
                     LPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGIL
                     KTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLD
                     QAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPER
                     ASSVYTRSTGEQEISVGL"
     STS             965..1394
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /standard_name="D3S4504"
                     /db_xref="UniSTS:474434"
     STS             1194..1377
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /standard_name="RH65248"
                     /db_xref="UniSTS:88902"
     STS             1206..1382
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
                     /standard_name="STS-X91492"
                     /db_xref="UniSTS:43626"
     polyA_signal    3638..3643
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
     polyA_site      3661
                     /gene="CCR5"
                     /gene_synonym="CKR5"
                     /gene_synonym="CD195"
                     /gene_synonym="CKR-5"
                     /gene_synonym="CCCKR5"
                     /gene_synonym="CMKBR5"
                     /gene_synonym="CC-CKR-5"
ORIGIN      
        1 cttcagatag attatatctg gagtgaagaa tcctgccacc tatgtatctg gcatagtatt
       61 ctgtgtagtg ggatgagcag agaacaaaaa caaaataatc cagtgagaaa agcccgtaaa
      121 taaaccttca gaccagagat ctattctcta gcttatttta agctcaactt aaaaagaaga
      181 actgttctct gattcttttc gccttcaata cacttaatga tttaactcca ccctccttca
      241 aaagaaacag catttcctac ttttatactg tctatatgat tgatttgcac agctcatctg
      301 gccagaagag ctgagacatc cgttccccta caagaaactc tccccgggtg gaacaagatg
      361 gattatcaag tgtcaagtcc aatctatgac atcaattatt atacatcgga gccctgccaa
      421 aaaatcaatg tgaagcaaat cgcagcccgc ctcctgcctc cgctctactc actggtgttc
      481 atctttggtt ttgtgggcaa catgctggtc atcctcatcc tgataaactg caaaaggctg
      541 aagagcatga ctgacatcta cctgctcaac ctggccatct ctgacctgtt tttccttctt
      601 actgtcccct tctgggctca ctatgctgcc gcccagtggg actttggaaa tacaatgtgt
      661 caactcttga cagggctcta ttttataggc ttcttctctg gaatcttctt catcatcctc
      721 ctgacaatcg ataggtacct ggctgtcgtc catgctgtgt ttgctttaaa agccaggacg
      781 gtcacctttg gggtggtgac aagtgtgatc acttgggtgg tggctgtgtt tgcgtctctc
      841 ccaggaatca tctttaccag atctcaaaaa gaaggtcttc attacacctg cagctctcat
      901 tttccataca gtcagtatca attctggaag aatttccaga cattaaagat agtcatcttg
      961 gggctggtcc tgccgctgct tgtcatggtc atctgctact cgggaatcct aaaaactctg
     1021 cttcggtgtc gaaatgagaa gaagaggcac agggctgtga ggcttatctt caccatcatg
     1081 attgtttatt ttctcttctg ggctccctac aacattgtcc ttctcctgaa caccttccag
     1141 gaattctttg gcctgaataa ttgcagtagc tctaacaggt tggaccaagc tatgcaggtg
     1201 acagagactc ttgggatgac gcactgctgc atcaacccca tcatctatgc ctttgtcggg
     1261 gagaagttca gaaactacct cttagtcttc ttccaaaagc acattgccaa acgcttctgc
     1321 aaatgctgtt ctattttcca gcaagaggct cccgagcgag caagctcagt ttacacccga
     1381 tccactgggg agcaggaaat atctgtgggc ttgtgacacg gactcaagtg ggctggtgac
     1441 ccagtcagag ttgtgcacat ggcttagttt tcatacacag cctgggctgg gggtggggtg
     1501 ggagaggtct tttttaaaag gaagttactg ttatagaggg tctaagattc atccatttat
     1561 ttggcatctg tttaaagtag attagatctt ttaagcccat caattataga aagccaaatc
     1621 aaaatatgtt gatgaaaaat agcaaccttt ttatctcccc ttcacatgca tcaagttatt
     1681 gacaaactct cccttcactc cgaaagttcc ttatgtatat ttaaaagaaa gcctcagaga
     1741 attgctgatt cttgagttta gtgatctgaa cagaaatacc aaaattattt cagaaatgta
     1801 caacttttta cctagtacaa ggcaacatat aggttgtaaa tgtgtttaaa acaggtcttt
     1861 gtcttgctat ggggagaaaa gacatgaata tgattagtaa agaaatgaca cttttcatgt
     1921 gtgatttccc ctccaaggta tggttaataa gtttcactga cttagaacca ggcgagagac
     1981 ttgtggcctg ggagagctgg ggaagcttct taaatgagaa ggaatttgag ttggatcatc
     2041 tattgctggc aaagacagaa gcctcactgc aagcactgca tgggcaagct tggctgtaga
     2101 aggagacaga gctggttggg aagacatggg gaggaaggac aaggctagat catgaagaac
     2161 cttgacggca ttgctccgtc taagtcatga gctgagcagg gagatcctgg ttggtgttgc
     2221 agaaggttta ctctgtggcc aaaggagggt caggaaggat gagcatttag ggcaaggaga
     2281 ccaccaacag ccctcaggtc agggtgagga tggcctctgc taagctcaag gcgtgaggat
     2341 gggaaggagg gaggtattcg taaggatggg aaggagggag gtattcgtgc agcatatgag
     2401 gatgcagagt cagcagaact ggggtggatt tgggttggaa gtgagggtca gagaggagtc
     2461 agagagaatc cctagtcttc aagcagattg gagaaaccct tgaaaagaca tcaagcacag
     2521 aaggaggagg aggaggttta ggtcaagaag aagatggatt ggtgtaaaag gatgggtctg
     2581 gtttgcagag cttgaacaca gtctcaccca gactccaggc tgtctttcac tgaatgcttc
     2641 tgacttcata gatttccttc ccatcccagc tgaaatactg aggggtctcc aggaggagac
     2701 tagatttatg aatacacgag gtatgaggtc taggaacata cttcagctca cacatgagat
     2761 ctaggtgagg attgattacc tagtagtcat ttcatgggtt gttgggagga ttctatgagg
     2821 caaccacagg cagcatttag cacatactac acattcaata agcatcaaac tcttagttac
     2881 tcattcaggg atagcactga gcaaagcatt gagcaaaggg gtcccataga ggtgagggaa
     2941 gcctgaaaaa ctaagatgct gcctgcccag tgcacacaag tgtaggtatc attttctgca
     3001 tttaaccgtc aataggcaaa ggggggaagg gacatattca tttggaaata agctgccttg
     3061 agccttaaaa cccacaaaag tacaatttac cagcctccgt atttcagact gaatgggggt
     3121 ggggggggcg ccttaggtac ttattccaga tgccttctcc agacaaacca gaagcaacag
     3181 aaaaaatcgt ctctccctcc ctttgaaatg aatatacccc ttagtgtttg ggtatattca
     3241 tttcaaaggg agagagagag gtttttttct gttctgtctc atatgattgt gcacatactt
     3301 gagactgttt tgaatttggg ggatggctaa aaccatcata gtacaggtaa ggtgagggaa
     3361 tagtaagtgg tgagaactac tcagggaatg aaggtgtcag aataataaga ggtgctactg
     3421 actttctcag cctctgaata tgaacggtga gcattgtggc tgtcagcagg aagcaacgaa
     3481 gggaaatgtc tttccttttg ctcttaagtt gtggagagtg caacagtagc ataggaccct
     3541 accctctggg ccaagtcaaa gacattctga catcttagta tttgcatatt cttatgtatg
     3601 tgaaagttac aaattgcttg aaagaaaata tgcatctaat aaaaaacacc ttctaaaata
     3661 aaaaaaaaaa aaaaaaaaaa aaaaaa
//

REFERENCE   9  (bases 1 to 3686)
  AUTHORS   Ann,D.K., Wu,M.M., Huang,T., Carlson,D.M. and Wu,R.
  TITLE     Retinol-regulated gene expression in human tracheobronchial
            epithelial cells. Enhanced expression of elongation factor EF-1
            alpha
  JOURNAL   J. Biol. Chem. 263 (8), 3546-3549 (1988)
   PUBMED   
REFERENCE   8  (bases 1 to 3686)
  AUTHORS   Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
  TITLE     Isolation and characterization of the human chromosomal gene for
            polypeptide chain elongation factor-1 alpha
  JOURNAL   J. Biol. Chem. 264 (10), 5791-5798 (1989)
   PUBMED   
REFERENCE   7  (bases 1 to 3686)
  AUTHORS   Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
            Hart,G.W.
  TITLE     Murine elongation factor 1 alpha (EF-1 alpha) is
            posttranslationally modified by novel amide-linked
            ethanolamine-phosphoglycerol moieties. Addition of
            ethanolamine-phosphoglycerol to specific glutamic acid residues on
            EF-1 alpha
  JOURNAL   J. Biol. Chem. 264 (24), 14334-14341 (1989)
   PUBMED   
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3686)
  AUTHORS   Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
  TITLE     Retropseudogenes constitute the major part of the human elongation
            factor 1 alpha gene family
  JOURNAL   Nucleic Acids Res. 18 (6), 1513-1516 (1990)
   PUBMED   
LOCUS       NM_000579               3686 bp    mRNA    linear   PRI 16-NOV-2008
DEFINITION  Homo sapiens chemokine (C-C motif) receptor 5 (CCR5), transcript
            variant A, mRNA.
ACCESSION   NM_000579 XM_001125981
VERSION     NM_000579.3  GI:154091329
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM