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1: GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D [ Homo sapiens ]

GeneID: 2906 updated 12-Nov-2008

[Top][Help]Summary

Official Symbol: GRIN2Dprovided by HGNC
Official Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2Dprovided by HGNC
Primary source: HGNC:4588
See related: Ensembl:ENSG 00000105464; HPRD:04095; MIM:602717
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EB11; NMDAR2D; GRIN2D

[Top][Help]Genomic regions, transcripts, and products

Go to reference sequence details Try our new Sequence Viewer

Genomic context[Top][Help]

chromosome: 19; Location: 19q13.1-qterSee GRIN2D in MapViewer

[Top][Help]Bibliography

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Observational study of gene-disease association. (HuGE Navigator)

2. Observational study of gene-disease association. (HuGE Navigator)

3. Observational study of gene-disease association. (HuGE Navigator)

4. data show that the NMDAR2D was specifically expressed in cultivated keratinocytes

Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein Interaction

1.Envelope surface glycoprotein gp120 HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed

2. HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed

3. HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

4. HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed

5.Tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........

Product Interactant Other Gene Complex Source Pubs

NMDAR2D NP_055717.2 DLGAP4 HPRD PubMed

NMDAR2D NP_004399.1 DNM1 HPRD PubMed

NMDAR2D NP_001385.1 DUSP4 HPRD PubMed

NMDAR2D NP_733750.2 INADL HPRD PubMed

NMDAR2D NP_114034.1 MAP2 HPRD PubMed

NMDAR2D NP_955631.1 NANOS1 HPRD PubMed

NMDAR2D NP_055040.2 PPP2R1A HPRD PubMed

NMDAR2D NP_006763.1 SYNGAP1 HPRD PubMed

NMDAR2D NP_003248.2 TJP1 HPRD PubMed

NP_000827.1 NP_005148.1 ABL1 HPRD PubMed

NP_000827.1 Synapse associated protein 90 DLG4 HPRD PubMed

NP_000827.1 NP_015566.1 GRIN1 HPRD PubMed

NP_000827.1 Interleukin 16 IL16 HPRD PubMed

in vitro; in vivo; Two-hybrid

BioGRID:109163 BioGRID:108086 DLG4 BioGRID PubMed

in vitro; Two-hybrid

BioGRID:109163 BioGRID:109816 IL16 BioGRID PubMed

[Top][Help]General gene information

Genotypes

See GRIN2D SNP GeneView Report
See GRIN2D SNP Genotype Report

Pathways

KEGG pathway: Calcium signaling pathway: 04020
KEGG pathway: Long-term potentiation: 04720
KEGG pathway: Neuroactive ligand-receptor interaction: 04080

Homology

Mouse, Rat: Map Viewer

GeneOntology Provided by GOA

Function Evidence

N-methyl-D-aspartate selective glutamate receptor activity IEA

calcium ion binding IEA

extracellular-glutamate-gated ion channel activity IEA

ion channel activity IEA

magnesium ion binding IEA

receptor activity IEA

Process Evidence

adult locomotory behavior IEA

ion transport IEA

regulation of sensory perception of pain IEA

signal transduction
PubMed 9480759 NAS PubMed

startle response IEA

Component Evidence

cell junction IEA

integral to membrane IEA

plasma membrane IEA

postsynaptic membrane IEA

synapse IEA

synaptosome IEA

[Top][Help]General protein information

Preferred Names: N-methyl-D-aspartate receptor subunit 2D

Names: N-methyl-D-aspartate receptor subunit 2D; estrogen receptor binding CpG island

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

NM_000836.2→NP_000827.2 N-methyl-D-aspartate receptor subunit 2D precursor

Source sequence(s)

AB209292,AW139866,U77783

Consensus CDS

CCDS12719.1

UniProtKB/Swiss-Prot

O15399

Conserved Domains (4) summary

cd00134 Location:486–575 Blast Score:144 Location:709–824 Blast Score:140: PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...
pfam00060 Location:582–866 Blast Score:599: Lig_chan; Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
cd06378 Location:49–418 Blast Score:1129: PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning...