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1: GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C [ Homo sapiens ]

GeneID: 2905 updated 12-Nov-2008

[Top][Help]Summary

Official Symbol: GRIN2Cprovided by HGNC
Official Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2Cprovided by HGNC
Primary source: HGNC:4587
See related: Ensembl:ENSG 00000161509; HPRD:00699; MIM:138254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NR2C; NMDAR2C; GRIN2C

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence details Try our new Sequence Viewer

Genomic context[Top][Help]

chromosome: 17; Location: 17q25See GRIN2C in MapViewer

[Top][Help]Bibliography

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Observational study of gene-disease association. (HuGE Navigator)

2. Observational study of gene-disease association. (HuGE Navigator)

Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein Interaction

1.Envelope surface glycoprotein gp120 HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed

2. HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed

3. HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

4. HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed

5.Tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........

Product Interactant Other Gene Complex Source Pubs

N-methyl D-aspartate receptor subunit 2C NP_733750.2 INADL HPRD PubMed

NP_000826.1 Synapse associated protein 102 DLG3 HPRD PubMed

NP_000826.1 NP_001356.1 DLG4 HPRD PubMed

NP_000826.1 Interleukin 16 IL16 HPRD PubMed

NP_000826.1 CIPP HPRD PubMed

in vitro; in vivo

BioGRID:109162 BioGRID:108085 DLG3 BioGRID PubMed

in vitro; in vivo; Two-hybrid

BioGRID:109162 BioGRID:108086 DLG4 BioGRID PubMed

Reconstituted Complex

BioGRID:109162 BioGRID:120997 ERBB2IP BioGRID PubMed

Two-hybrid

BioGRID:109162 BioGRID:109816 IL16 BioGRID PubMed

[Top][Help]General gene information

Genotypes

See GRIN2C SNP GeneView Report
See GRIN2C SNP Genotype Report

Pathways

KEGG pathway: Calcium signaling pathway: 04020
KEGG pathway: Long-term potentiation: 04720
KEGG pathway: Neuroactive ligand-receptor interaction: 04080

Homology

Mouse, Rat: Map Viewer

GeneOntology Provided by GOA

Function Evidence

N-methyl-D-aspartate selective glutamate receptor activity IEA

N-methyl-D-aspartate selective glutamate receptor activity
PubMed 9798920 TAS PubMed

calcium ion binding IEA

cation channel activity IEA

extracellular-glutamate-gated ion channel activity IEA

glutamate receptor binding IEA

ion channel activity IEA

magnesium ion binding IEA

protein binding IEA

receptor activity IEA

Process Evidence

directional locomotion IEA

glutamate signaling pathway
PubMed 9798920 TAS PubMed

ion transport IEA

negative regulation of protein catabolic process IEA

neuromuscular process controlling balance IEA

protein localization IEA

regulation of excitatory postsynaptic membrane potential IEA

regulation of membrane potential IEA

regulation of synaptic plasticity IEA

response to wounding IEA

Component Evidence

N-methyl-D-aspartate selective glutamate receptor complex IEA

cell junction IEA

integral to membrane IEA

integral to plasma membrane
PubMed 9798920 TAS PubMed

plasma membrane IEA

postsynaptic density IEA

postsynaptic membrane IEA

synapse IEA

[Top][Help]General protein information

Preferred Names: N-methyl-D-aspartate receptor subunit 2C

Names: N-methyl-D-aspartate receptor subunit 2C

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

NM_000835.3→NP_000826.2 N-methyl-D-aspartate receptor subunit 2C precursor

Source sequence(s)

L76224,U77782

Consensus CDS

CCDS32724.1

UniProtKB/TrEMBL

O15398

Conserved Domains (4) summary

cd00134 Location:456–545 Blast Score:140 Location:636–794 Blast Score:139: PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...
pfam00060 Location:552–836 Blast Score:584: Lig_chan; Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
cd06378 Location:28–389 Blast Score:1477: PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning...