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1: GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B [ Homo sapiens ]
GeneID: 2904 updated 12-Nov-2008
- Official Symbol
- GRIN2Bprovided by HGNC
- Official Full Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 2Bprovided by HGNC
- Primary source
- HGNC:4586
- See related
- Ensembl:ENSG00000150086; HPRD:00697; MIM:138252
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
- Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- NR2B; hNR3; NMDAR2B; MGC142178; MGC142180; GRIN2B
- Summary
- N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq]
[Top][Help]Genomic regions, transcripts, and products
chromosome: 12; Location: 12p12See GRIN2B in MapViewer
![[image]](http://mowser.com/img?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fsutils%2Fgeneneighb.fcgi%3Fgeneid%3D2904%26n0%3DEMP1%26n1%3DC12orf36%26n2%3DGRIN2B%26n3%3DLOC644693%26n4%3DATF7IP)
Related Articles in PubMed
GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?
1. Observational study of gene-disease association. (HuGE Navigator) 2. The interaction between NR2B subunit and Mind bomb-2 reveal a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination.
3. GRIN2B gene is associated with Alzheimer's disease.
4. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.
5. the synaptic NMDA receptor extracellular signal-regulated kinase activation pathway is coupled to both NR2A and NR2B containing receptors
6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
8. Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator)
9. Observational study of gene-disease association. (HuGE Navigator)
10. Observational study of gene-disease association. (HuGE Navigator)
11. Observational study of gene-disease association. (HuGE Navigator)
12. Observational study of gene-disease association. (HuGE Navigator)
13. Observational study of gene-disease association. (HuGE Navigator)
14. Observational study of gene-disease association. (HuGE Navigator)
15. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16. Observational study of gene-disease association. (HuGE Navigator)
17. Observational study of gene-disease association. (HuGE Navigator)
18. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19. Observational study of gene-disease association. (HuGE Navigator)
20. Observational study of gene-disease association. (HuGE Navigator)
21. Observational study of gene-disease association. (HuGE Navigator)
22. Observational study of gene-disease association. (HuGE Navigator)
23. Observational study of gene-disease association. (HuGE Navigator)
24. Observational study of gene-disease association. (HuGE Navigator)
25. Observational study of gene-disease association. (HuGE Navigator)
26. Observational study of gene-disease association. (HuGE Navigator)
27. Observational study of gene-disease association. (HuGE Navigator)
28. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
29. Observational study of gene-disease association. (HuGE Navigator)
30. Laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells
31. genetic variations in the human GRIN2B gene probably do not play a major role in susceptibility to, or severity of Tardive dyskinesia
32. results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation
33. NMDAR2B methylation is a common and important biologically relevant event in gastric cancer progression
34. data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.
35. hypothesis that the allelic variant (C2664T) of the NR2b confers susceptibility to AD .
36. Results describe the successful replacement of murine N-methyl-d-aspartate receptor (NR)2B gene function by "knocking-in" a chimeric human NR2A/B cDNA containing the minimal domain abolishing ifenprodil binding into the endogenous NR2B locus.
37. Increased coassembly of NR2B and NR1 with PSD-95 may underlie one of the cellular mechanisms that contributes to in situ increased hyperexcitability, leading to seizure generation in focal cortical dysplasia.
38. These results provide evidence that GRIN2B may be associated with susceptibility to OCD.
39. Variants in NMDAR genes are associated with alcoholism and related traits.
40. These findings suggest new candidate SNPs(rs1806201) in GRIN2B for studying the genetic susceptibility to alcoholism.
41. Reviews the role of altered structure and function of NMDA receptors after ethanol exposure and summarizes the recent data about the activity of NR2B subunit selective NMDA receptor antagonists in model systems related to alcoholism.
42. It is unlikely that the GRIN2B C2664T polymorphism plays a substantial role in conferring susceptibility to Parkinson's disease in the Chinese population.
43. human cerebral endothelial cells express the message and protein for NMDA receptors.
44. The results show that GRIN2B genetic variations are not a major risk factor for treatment-refractory schizophrenic patients, but may influence the effect of clozapine during treatment.
45. novel mechanism for Ca2+-dependent negative-feedback regulation of NR2B-containing NMDARs in a CaMKII activity- and autophosphorylation-dependent manner that may modulate NMDAR-mediated synaptic plasticity
46. The results show evidence of a statistically significant association for GRIN2B. The association seems weaker, but nonetheless interesting
47. the three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit
48. The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
49. NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
50. The levels of Nr2B mRNA are decreased in Alzheimer disease hippocampus and entorhinal cortex compared to controls.
51. identification of a novel variant of the human gene promoter region and its possible association with schizophrenia
52. NR2B subtypes mainly expressed in the striatum, may influence the variability in age of onset of Huntington disease.
53. the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.
54. postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy
55. results suggest that GRIN2B single nucleotide polymorphisms might be linked with susceptibility to schizophrenia
56. These results demonstrate that human T lymphocytes express the NR2B subunit of NMDA receptors, which are functionally active in controlling cell activation.
57. NR2B was located in the midpiece of sperm, whereas GLT1 mainly existed in the head
[Top][Help]HIV-1 protein interactions
2. HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
3. HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
4. HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
5.Tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed
Go to the HIV-1, Human Protein Interaction Database
Description ..........
Product Interactant Other Gene Complex Source Pubs
NP_000825.1 Channel associated protein of synapse 110 DLG2 HPRD PubMed
MAGI3 interacts with NMDA receptor 2B.
Tiam1-NR1 complex interacts with NR2B. This interaction was modelled on a demonstrated interaction between human Tiam1-NR1 complex and NR2B from rat and an unspecified species.
in vivo
in vitro
Affinity Capture-Western
Affinity Capture-Western; in vitro; in vivo
Affinity Capture-Western; in vitro; in vivo
Affinity Capture-Western; in vitro; in vivo; Two-hybrid
Reconstituted Complex
Affinity Capture-Western
Affinity Capture-Western
Reconstituted Complex
in vitro
in vitro; in vivo
in vivo
Two-hybrid
in vitro
in vitro; in vivo
Two-hybrid
in vitro; in vivo
Affinity Capture-Western; Reconstituted Complex; Two-hybrid
in vitro; in vivo
[Top][Help]General gene information
Markers
- G11784(e-PCR)
- Links: UniSTS:7908
- Alternate name: WI-10005
- G41299(e-PCR)
- Links: UniSTS:12850
- Alternate name: B224C2/SP6
- G41304(e-PCR)
- Links: UniSTS:23496
- Alternate name: B103N14/SP6
- D12S2089(e-PCR)
- Links: UniSTS:29848
- Alternate names: G00-701-944; GDB:701944; MR6184; RH52809; WI-4051
- D12S364(e-PCR)
- Links: UniSTS:30766
- Alternate names: AFM345we1; RH582; RH71486; RH71513; SHGC-2154; SHGC-24339
- D12S847(e-PCR)
- Links: UniSTS:45945
- Alternate names: 929e11-R; GDB:335841
- D12S1946(e-PCR)
- Links: UniSTS:52167
- Alternate names: G00-677-764; GDB:677764; RH52777; RH9086; SHGC-12945; UTR-05542; WI-7972; WIAF-1189
- WI-18930(e-PCR)
- Links: UniSTS:58072
- Alternate names: HSA.1206; RH52749; STS-U11287
- SHGC-78950(e-PCR)
- Links: UniSTS:95830
- Alternate name: RH106156
- RH121528(e-PCR)
- Links: UniSTS:134269
- Alternate name: SHGC-102635
- G60183(e-PCR)
- Links: UniSTS:137442
- Alternate name: SHGC-131078
- G62303(e-PCR)
- Links: UniSTS:139270
- Alternate name: B22G23/SP6
- D12S1274(e-PCR)
- Links: UniSTS:151828
- Alternate name: GDB:456247
- SHGC-145043(e-PCR)
- Links: UniSTS:172512
- GRIN2B_968(e-PCR)
- Links: UniSTS:277297
- GRIN2B_V248(e-PCR)
- Links: UniSTS:277297
- GRIN2B(e-PCR)
- Links: UniSTS:480092
Pathways
- KEGG pathway: Long-term potentiation
- 04720
- KEGG pathway: Neuroactive ligand-receptor interaction
- 04080
Homology
GeneOntology Provided by GOA
[Top][Help]General protein information
- Preferred Names
- N-methyl-D-aspartate receptor subunit 2B
- Names
- N-methyl-D-aspartate receptor subunit 2B
- glutamate receptor subunit epsilon-2
[Top][Help]NCBI Reference Sequences (RefSeq)
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
NM_000834.3→NP_000825.2 N-methyl-D-aspartate receptor subunit 2B precursor
- Source sequence(s)
- AC007535,U88963,U90278
- Consensus CDS
- CCDS8662.1
- UniProtKB/Swiss-Prot
- Q13224
- Conserved Domains (4) summary
-
- cd00134
Location:682–797
Blast Score:125
Location:459–548
Blast Score:125
- PBPb; Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...
- pfam00060
Location:555–839
Blast Score:636
- Lig_chan; Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
- cd06378
Location:33–393
Blast Score:1608
- PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family. The ionotropic N-methyl-d-asparate (NMDA) subtype of glutamate receptor serves critical functions in neuronal development, functioning...
RefSeqs of Annotated Genomes: Build 36.3
The following sections contain reference sequences that belong to a specific genome build. Explain
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.
Reference assembly
Genomic