Official Symbol

ADRA2Aprovided by HGNC

Official Full Name

adrenergic, alpha-2A-, receptorprovided by HGNC

Primary source

HGNC:281

See related

Ensembl:ENSG00000150594; HPRD:00078; MIM:104210

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR; ADRA2A

Summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]

Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 10; Location: 10q24-q26See ADRA2A in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Observational study of gene-disease association. (HuGE Navigator)

2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

3. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

4. shows strong affinity to idazoxan and excists in MAO of mitochondria which has imidazoline-ligand binding sites in its molecule.

5. PAR4-pretreated platelets, epinephrine caused dense granule secretion, and subsequent signaling from the ATP-gated P2X(1)-receptor and the alpha(2A)-adrenergic receptor induced aggregation.

6. With CC and CG genotypes girls had higher scores on extraversion scales than boys, but with GG genotype boys score higher than girls with GG genotype.

7. Observational study of gene-disease association. (HuGE Navigator)

8. Observational study of gene-disease association. (HuGE Navigator)

9. Observational study of gene-disease association. (HuGE Navigator)

10. the influence of the G allele at the ADRA2A -1291 C > G polymorphism on the improvement of inattentive symptoms with methylphenidate in children with all ADHD subtypes.

11. Observational study of gene-disease association. (HuGE Navigator)

12. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

13. there is a role for the ADRA2A polymorphism in the predisposition to tobacco smoking

14. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

15. Observational study of gene-disease association. (HuGE Navigator)

16. Observational study of gene-disease association. (HuGE Navigator)

17. Observational study of gene-disease association. (HuGE Navigator)

18. Observational study of gene-disease association. (HuGE Navigator)

19. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

20. Observational study of gene-disease association. (HuGE Navigator)

21. Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

23. Observational study of gene-disease association. (HuGE Navigator)

24. Observational study of gene-disease association. (HuGE Navigator)

25. Observational study of gene-disease association. (HuGE Navigator)

26. Observational study of gene-disease association. (HuGE Navigator)

27. Observational study of gene-disease association. (HuGE Navigator)

28. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

29. Observational study of gene-disease association. (HuGE Navigator)

30. Observational study of gene-disease association. (HuGE Navigator)

31. Observational study of gene-disease association. (HuGE Navigator)

32. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

33. Observational study of gene-disease association. (HuGE Navigator)

34. Observational study of gene-disease association. (HuGE Navigator)

35. Observational study of gene-disease association. (HuGE Navigator)

36. Observational study of gene-disease association. (HuGE Navigator)

37. Observational study of gene-disease association. (HuGE Navigator)

38. Observational study of gene-disease association. (HuGE Navigator)

39. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

40. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)

41. Observational study of gene-disease association. (HuGE Navigator)

42. Observational study of gene-disease association. (HuGE Navigator)

43. Observational study of gene-disease association. (HuGE Navigator)

44. Observational study of genotype prevalence. (HuGE Navigator)

45. Observational study of gene-disease association. (HuGE Navigator)

46. Observational study of gene-disease association. (HuGE Navigator)

47. Observational study of gene-disease association. (HuGE Navigator)

48. Observational study of gene-environment interaction. (HuGE Navigator)

49. Observational study of gene-disease association. (HuGE Navigator)

50. Observational study of gene-disease association. (HuGE Navigator)

51. Observational study of gene-disease association. (HuGE Navigator)

52. Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)

53. Observational study of gene-disease association. (HuGE Navigator)

54. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

55. Observational study of gene-disease association. (HuGE Navigator)

56. Observational study of gene-disease association. (HuGE Navigator)

57. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

58. Observational study of gene-disease association. (HuGE Navigator)

59. Polymorphisms are not associated with Toureett's syndrome in this study.

60. In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation.

61. the inheritance of polymorphisms in the ADRA2A and ADRA1C genes in 113 nuclear families provided no significant evidence for linkage for these two genes; these genes are not major genetic factors contributing to the susceptibility to GTS

62. An interaction between beta(1)AR and alpha(2A)AR is regulated by glycosylation and may play a key role in cross-talk and mutual regulation between these receptors.

63. There seems to be a small effect of ADRA2A on attention deficit disorder with hyperactivity either as a susceptibility gene or as a modulator of its severity.

64. No association between ADRA2A polymorphisms and schizophrenia.

65. Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor

66. Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other.

67. GRK2 binding is critical not only for alpha2A-adrenergic receptor phosphorylation but also for full activity of the kinase.

68. Preliminary evidence for association of ADRA2A with comorbid ADHD and reading disability

69. a significant correlation was observed between the level of mRNA and protein quantified in the brain of the same subjects, indicating that protein synthesis of adrenergic, alpha-2A-, receptor was not influenced by post-translational regulatory mechanisms

70. Results provide weak evidence for a possible role of ADRA2A in attention-deficit/hyperactivity disorder symptom expression.

71. alpha 2-adrenergic receptor gene and body fat content and distribution: role for the ADRA2A gene in determining the propensity to store fat in the abdominal area, independent of total body fatness

72. These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking.

73. ADRA2A may be associated with attention-deficit/hyperactivity disorder (ADHD) inattentive symptoms.

74. Data demonstrate that the alpha(2A)AR evokes ERK phosphorylation through both an arrestin/Src-dependent and a Src-independent pathway, both of which are G protein dependent and converge on the Ras-Raf-MEK pathway.

75. In the present study it was found that stimulated alpha2-adrenergic receptors induce delayed transactivation of TrkA in PC12 cells.

76. This study supports the hypothesis that an allele of the ADRA2A gene is associated and linked with the ADHD combined subtype and suggests that the DraI polymorphism of ADRA2A is linked to a causative polymorphism.

77. Thus, the alpha(2C)AR alters alpha(2A)AR signaling by forming oligomers, and these complexes, which appear to be preferred over the homodimers, should be considered a functional signaling unit in cells in which both subtypes are expressed.

78. The C-1291G genotype had a significant effect on the consumption of ready-made sweet food products.

79. Our results show the genotype GG adrenergic alpha2a receptor with higher mean body weight gain than genotype CC. The finding identify a genetic factor associated with clozapine-induced weight gain in schizophrenic patients.

80. ADRA2A gene may be involved in attention deficit disorder with hyperactivity

81. we screened the sequence variations in the transcriptional region of ADRA2A gene and analyzed the relationship between the two common polymorphisms and platelet function

82. transgenic mouse with human alpha 2A receptors will serve as a model of diet-induced obesity

83. Common genetic ADRA2A variants are not important determinants of baseline cardiovascular measures (plasma norepinephrine, heart rate, and blood pressure) in healthy volunteers

84. Genetic and the binding studies indicate that the alpha-2 adrenergic receptor may play a role in attention deficit hyperactivity disorder.

85. Estrogen attenuates the lipolytic response through up-regulation of the number of antilipolytic alpha2A-adrenergic receptors only in sc and not in visceral fat depots.

86. ADRA2A and ADRA2B each had a single haplotype block at least 11 and 16 kb in size

87. Alpha2-ARs in vascular smooth muscle cells reflect differential activity of alpha2-AR gene promoters. Alpha2C-ARs can be induced via p38 MAPK-dependent pathway.

88. alpha(2A)-AR and MOR hetero-oligomers, although they occur, do not have an obligatory functional influence on one another

89. Both DraI restriction fragment length polymorphism in ADRA2A and ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks. (Alpha2 adrenergic receptors ADRA2A and ADRA2C)

90. results suggested that gg genotype and g allele at site -1296 in alpha(2A)-AR gene could associate with the susceptibility to motion sickness

Markers

Pathways

Homology

GeneOntology Provided by GOA

Preferred Names

alpha-2A-adrenergic receptor

Names

alpha-2A-adrenergic receptor

OTTHUMP00000058849

alpha-2A adrenoceptor

alpha-2AAR subtype C10

alpha2A adrenergic receptor

alpha-2-adrenergic receptor, platelet type

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

RefSeqs of Annotated Genomes: Build 36.3

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly

Genomic

Alternate assembly (based on Celera assembly)

Genomic

Alternate assembly (based on HuRef)

Genomic