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1: Adra2b adrenergic receptor, alpha 2b [ Mus musculus ]
GeneID: 11552 updated 12-Nov-2008
- Official Symbol
- Adra2bprovided by MGI
- Official Full Name
- adrenergic receptor, alpha 2bprovided by MGI
- Primary source
- MGI:87935
- Locus tag
- RP23-119A13.2
- See related
- Ensembl:ENSMUSG00000058620
- Gene type
- protein coding
- RefSeq status
- VALIDATED
- Organism
- Mus musculus
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus
- Also known as
- [a]2B; Adra-2b; alpha2B; alpha2-C2; Adra2b
[Top][Help]Genomic regions, transcripts, and products
chromosome: 2; Locations: 2 F1; 2 71.0 cMSee Adra2b in MapViewer
![[image]](http://mowser.com/img?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fsutils%2Fgeneneighb.fcgi%3Fgeneid%3D11552%26n0%3DDusp2%26n1%3DAstl%26n2%3DAdra2b%26n3%3DA530057A0...%26n4%3DFahd2a)
Related Articles in PubMed
GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?
1. alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta. 2. Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase inhibition.
3. by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin reduces arrestin- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase activity after endocytosis
4. alpha2B adrenoceptor regulated expression is examined in mouse brain development
Alleles of this type are documented at Mouse Genome Informatics (MGI)
Description ..........
Product Interactant Other Gene Complex Source Pubs
eIF2B-alpha interacts with the cytoplasmic, carboxy-terminus of the alpha-2B adrenergic receptor. This interaction was modeled on a demonstrated interaction between eIF2B-alpha from human and alpha-2B-AR from mouse.
[Top][Help]General gene information
Markers
Pathways
- KEGG pathway: Neuroactive ligand-receptor interaction
- 04080
Homology
GeneOntology Provided by MGI
[Top][Help]General protein information
- Preferred Names
- adrenergic receptor, alpha 2b
- Names
- adrenergic receptor, alpha 2b
- subtype alpha2-C2
[Top][Help]NCBI Reference Sequences (RefSeq)
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
NM_009633.3→NP_033763.2 adrenergic receptor, alpha 2b
- Source sequence(s)
- AL731836
- Consensus CDS
- CCDS16701.1
- Conserved Domains (2) summary
-
- cl09500
Location:34–225
Blast Score:386
Location:348–429
Blast Score:113
- 7tm_1; 7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs...
RefSeqs of Annotated Genomes: Build 37.1
The following sections contain reference sequences that belong to a specific genome build. Explain
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.
Reference assembly (C57BL/6J)
Genomic
Alternate assembly (based on Celera)
Genomic
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