Official Symbol

Adra2aprovided by MGI

Official Full Name

adrenergic receptor, alpha 2aprovided by MGI

Primary source

MGI:87934

See related

Ensembl:ENSMUSG00000033717

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Mus musculus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus

Also known as

Adra-2; Adra-2a; alpha2A; AW122659; alpha2-C10; alpha2A-AR; alpha(2A)AR; Adra2a

Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 19; Locations: 19 D2; 19 50.0 cMSee Adra2a in MapViewer

Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

1. Demonstrate a key role for the alpha(2A)-adrenoceptor in adrenergic regulation of blood glucose and insulin homeostasis.

2. gene-targeted mice carrying deletions in the genes encoding alpha2A-adrenoceptors have provided new insight into adrenergic receptor biology--REVIEW

3. the involvement of hippocampal alpha(2A)-AR in the regulation of ambulatory activity induced by METH administration.

4. In wild-type mice, all vessels occluded irreversibly, whereas in 24% of alpha(2A)-deficient mice, the initially formed thrombi embolized and blood flow was reestablished, demonstrating that alpha(2A) plays a significant role in thrombus stabilization

5. by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin reduces arrestin- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase activity after endocytosis

6. 8-OH-DPAT binds to alpha(2A) receptor binding sites in wild-type mouse brain.

7. functional loss of the alpha2A-AR, unlike knock-out of the alpha2C-AR, weakened performance of a prefrontal cortical task without affecting learning and resulted in loss of the beneficial response to guanfacine

8. Data demonstrate that the alpha(2A)AR evokes ERK phosphorylation through both an arrestin/Src-dependent and a Src-independent pathway, both of which are G protein dependent and converge on the Ras-Raf-MEK pathway.

9. adrenaline inhibits insulin release through alpha(2A)- and alpha(2C)-adrenergic receptors via distinct intracellular signaling pathways

10. Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.

11. alpha2a-adrenergic receptors play a prominent role in the postnatal development of the respiratory pattern and that the alpha2a receptor is the subtype involved in the respiratory depressive effects of alpha2-adrenergic agonists.

12. Alpha-2 adrenoceptors exert a regulatory influence on autonomic cardiovascular control and baroreflex function. The effect of clonidine on baroreflex HR regulation is mediated by the parasympathetic nervous system.

13. In conclusion, this study indicates that AR gene expression is affected by these hormones in both preadipocytes and adipocytes.

14. The alpha 2A-adrenoceptor mediates in vivo the inhibition of intestinal motility by the sympathetic nervous system.

15. Alpha2A-adrenergic receptors mediate sympathoinhibitory responses to atrial natriuretic peptide in the anterior hypothalamic nucleus.

16. This study suggests that alpha2A ARs are involved in the development of the central noradrenergic system and raises the possibility that alterations in alpha2A AR expression may contribute to variations in fear and stress responses

[Top][Help]Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Markers

Pathways

Homology

GeneOntology Provided by MGI

Preferred Names

adrenergic receptor, alpha 2a

Names

adrenergic receptor, alpha 2a

subtype alpha2-C10

alpha2A-adrenergic receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference assembly (C57BL/6J)

Genomic