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1: FEBS Lett. 1991 Mar 25;280(2):241-4.
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Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

Chhajlani V, Rangel N, Uhlén S, Wikberg JE.

Department of Pharmacology, Umeå University, Sweden.

We here describe the cloning of an additional gene, called alpha 2-1.8, which is similar to the previously cloned human alpha 2-adrenergic receptor located on chromosome 4. The alpha 2-1.8 gene was identified by using the polymerase chain reaction with primers specific for sequences in transmembrane regions 2 and 5 of the previously isolated human alpha 2-C4 and alpha 2-C10 adrenoceptor genes, which are localized on chromosomes 4 and 10, respectively. The new gene was identified by amplifying the 1.8 kb size fractionated region of PstI restriction cut human genomic DNA. The previously cloned alpha 2-C10 and alpha 2-C4 genes were recovered at their expected locations, 0.96 and 5.9 kb, respectively. We have identified 387 bases of the new alpha 2-1.8 gene, and its sequence is identical to the previously described alpha 2-C4 gene, but it is distinct from the alpha 2-C10 and alpha 2-C2 genes. Our results demonstrate that the alpha 2-C4 adrenergic receptor exists in more than one copy in the human genome.

Publication Types:
Research Support, Non-U.S. Gov't

PMID: 1849485 [PubMed - indexed for MEDLINE]

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