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GO:0007186 G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

Term Information

GO:0007186

G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

Synonyms

Type Synonym

exact G protein coupled receptor protein signaling pathway

exact GPCR protein signalling pathway

exact GPCR protein signaling pathway

exact G-protein coupled receptor protein signalling pathway

exact G-protein coupled receptor protein signal transduction

exact G-protein-coupled receptor protein signaling pathway

exact G-protein-coupled receptor protein signalling pathway

exact G protein coupled receptor protein signalling pathway

Cross-references associated with this term:

Database ID

INTERPRO IPR000018

INTERPRO IPR000068

INTERPRO IPR000112

INTERPRO IPR000142

INTERPRO IPR000147

INTERPRO IPR005397

INTERPRO IPR005396

INTERPRO IPR005395

INTERPRO IPR005394

INTERPRO IPR005393

INTERPRO IPR005392

INTERPRO IPR005391

INTERPRO IPR004072

INTERPRO IPR004071

INTERPRO IPR004070

INTERPRO IPR004069

INTERPRO IPR004068

INTERPRO IPR004067

INTERPRO IPR004066

INTERPRO IPR004065

INTERPRO IPR004064

INTERPRO IPR004063

INTERPRO IPR004062

INTERPRO IPR004061

INTERPRO IPR004060

INTERPRO IPR004059

INTERPRO IPR003986

INTERPRO IPR003985

INTERPRO IPR003984

INTERPRO IPR003983

INTERPRO IPR003982

INTERPRO IPR003981

INTERPRO IPR003980

INTERPRO IPR003944

INTERPRO IPR003943

INTERPRO IPR001184

INTERPRO IPR001168

INTERPRO IPR001151

INTERPRO IPR001116

INTERPRO IPR001115

INTERPRO IPR001112

INTERPRO IPR001105

INTERPRO IPR001069

INTERPRO IPR001068

INTERPRO IPR001053

INTERPRO IPR001019

INTERPRO IPR001013

INTERPRO IPR001004

INTERPRO IPR000987

INTERPRO IPR000986

INTERPRO IPR000984

INTERPRO IPR000935

INTERPRO IPR000929

INTERPRO IPR000921

INTERPRO IPR000913

INTERPRO IPR000856

INTERPRO IPR000848

INTERPRO IPR000832

INTERPRO IPR000826

INTERPRO IPR000820

INTERPRO IPR000810

INTERPRO IPR000761

INTERPRO IPR000735

INTERPRO IPR000732

INTERPRO IPR000725

INTERPRO IPR000723

INTERPRO IPR000708

INTERPRO IPR000681

INTERPRO IPR000670

INTERPRO IPR000654

INTERPRO IPR000628

INTERPRO IPR000621

INTERPRO IPR000611

INTERPRO IPR000610

INTERPRO IPR000599

INTERPRO IPR000596

INTERPRO IPR000586

INTERPRO IPR000507

INTERPRO IPR000505

INTERPRO IPR000503

INTERPRO IPR000499

INTERPRO IPR000497

INTERPRO IPR000496

INTERPRO IPR000482

INTERPRO IPR000469

INTERPRO IPR000466

INTERPRO IPR000455

INTERPRO IPR000452

INTERPRO IPR000450

INTERPRO IPR000431

INTERPRO IPR000405

INTERPRO IPR000393

INTERPRO IPR000378

INTERPRO IPR000377

INTERPRO IPR000351

INTERPRO IPR000337

INTERPRO IPR000332

INTERPRO IPR000321

INTERPRO IPR000314

INTERPRO IPR000276

INTERPRO IPR000265

INTERPRO IPR000248

INTERPRO IPR000207

INTERPRO IPR000204

INTERPRO IPR000202

INTERPRO IPR000190

INTERPRO IPR000162

INTERPRO IPR000161

INTERPRO IPR000155

INTERPRO IPR000154

INTERPRO IPR000376

INTERPRO IPR000371

INTERPRO IPR000370

INTERPRO IPR000367

INTERPRO IPR000363

INTERPRO IPR000356

INTERPRO IPR000355

INTERPRO IPR000144

INTERPRO IPR000141

INTERPRO IPR013313

INTERPRO IPR013312

INTERPRO IPR017983

INTERPRO IPR017979

INTERPRO IPR017978

INTERPRO IPR015898

INTERPRO IPR015695

INTERPRO IPR015531

INTERPRO IPR005390

INTERPRO IPR005389

INTERPRO IPR005388

INTERPRO IPR005387

INTERPRO IPR005386

INTERPRO IPR005385

INTERPRO IPR005384

INTERPRO IPR005383

INTERPRO IPR005382

INTERPRO IPR009106

INTERPRO IPR011500

INTERPRO IPR009133

INTERPRO IPR009132

INTERPRO IPR009126

INTERPRO IPR008365

INTERPRO IPR008362

INTERPRO IPR008361

INTERPRO IPR008109

INTERPRO IPR007960

INTERPRO IPR003912

INTERPRO IPR003909

INTERPRO IPR003908

INTERPRO IPR003907

INTERPRO IPR003906

INTERPRO IPR003905

INTERPRO IPR003904

INTERPRO IPR003334

INTERPRO IPR003292

INTERPRO IPR003291

INTERPRO IPR003290

INTERPRO IPR003289

INTERPRO IPR003288

INTERPRO IPR003287

INTERPRO IPR002976

INTERPRO IPR002975

INTERPRO IPR002962

INTERPRO IPR002457

INTERPRO IPR002456

INTERPRO IPR002455

INTERPRO IPR002286

INTERPRO IPR002285

INTERPRO IPR002284

INTERPRO IPR002282

INTERPRO IPR002281

INTERPRO IPR002280

INTERPRO IPR002279

INTERPRO IPR002278

INTERPRO IPR002277

INTERPRO IPR002276

INTERPRO IPR002275

INTERPRO IPR002274

INTERPRO IPR002273

INTERPRO IPR002272

INTERPRO IPR002258

INTERPRO IPR002240

INTERPRO IPR002239

INTERPRO IPR002238

INTERPRO IPR002237

INTERPRO IPR002236

INTERPRO IPR002235

INTERPRO IPR002234

INTERPRO IPR002233

INTERPRO IPR002232

INTERPRO IPR002231

INTERPRO IPR002230

INTERPRO IPR002228

INTERPRO IPR002206

INTERPRO IPR002188

INTERPRO IPR002185

INTERPRO IPR002175

INTERPRO IPR002147

INTERPRO IPR002131

INTERPRO IPR002122

INTERPRO IPR002120

INTERPRO IPR002074

INTERPRO IPR002062

INTERPRO IPR002002

INTERPRO IPR001973

INTERPRO IPR001966

INTERPRO IPR001946

INTERPRO IPR001933

INTERPRO IPR001923

INTERPRO IPR001922

INTERPRO IPR001908

INTERPRO IPR001883

INTERPRO IPR001856

INTERPRO IPR001817

INTERPRO IPR001793

INTERPRO IPR001786

INTERPRO IPR001771

INTERPRO IPR001770

INTERPRO IPR001760

INTERPRO IPR001758

INTERPRO IPR001749

INTERPRO IPR001740

INTERPRO IPR001735

INTERPRO IPR001718

INTERPRO IPR001681

INTERPRO IPR001671

INTERPRO IPR001658

INTERPRO IPR001644

INTERPRO IPR001642

INTERPRO IPR001634

INTERPRO IPR001620

INTERPRO IPR001571

INTERPRO IPR001560

INTERPRO IPR001556

INTERPRO IPR001551

INTERPRO IPR001521

INTERPRO IPR001520

INTERPRO IPR001513

INTERPRO IPR001512

INTERPRO IPR001504

INTERPRO IPR009150

INTERPRO IPR009144

INTERPRO IPR006030

INTERPRO IPR005466

INTERPRO IPR001499

INTERPRO IPR001481

INTERPRO IPR001458

INTERPRO IPR001435

INTERPRO IPR001420

INTERPRO IPR001418

INTERPRO IPR001416

INTERPRO IPR001413

INTERPRO IPR001408

INTERPRO IPR001402

INTERPRO IPR001397

INTERPRO IPR001391

INTERPRO IPR001358

INTERPRO IPR001350

INTERPRO IPR001277

INTERPRO IPR001274

INTERPRO IPR001256

INTERPRO IPR001244

INTERPRO IPR001234

INTERPRO IPR001224

INTERPRO IPR001186

INTERPRO IPR000105

INTERPRO IPR000025

INTERPRO IPR000046

Web service: term information

Format Description

mini Mini HTML, suitable for dynamically embedding in popup boxes

obo OBO format snippet

oboxml OBO XML format snippet

oldxml Old XML format

Use this URI template to access this data as a service

GTerm?id=termID&format=format

Example clients are available in: java

Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

All GO terms displayed in this graph can be right-clicked to display term definitions and child (descendent) terms.

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.

GO:0008150 biological_process

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GO:0009987 cellular process

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GO:0050789 regulation of biological process

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GO:0050794 regulation of cellular process

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GO:0065007 biological regulation

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GO:0007154 cell communication

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GO:0007165 signal transduction

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GO:0007166 cell surface receptor linked signal transduction

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GO:0007186 G-protein coupled receptor protein signaling pathway

Relationship key

Code

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part of

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is a

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regulates

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+ve regulates

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-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:

R

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GO:0008277 regulation of G-protein coupled receptor protein signaling pathway

I

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GO:0000750 pheromone-dependent signal transduction during conjugation with cellular fusion

I

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GO:0000757 signal transduction during conjugation without cellular fusion

I

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GO:0042699 follicle-stimulating hormone signaling pathway

I

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GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger

I

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GO:0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

I

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GO:0007210 serotonin receptor signaling pathway

I

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GO:0007211 octopamine/tyramine signaling pathway

I

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GO:0007212 dopamine receptor signaling pathway

I

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GO:0007213 acetylcholine receptor signaling, muscarinic pathway

I

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GO:0007214 gamma-aminobutyric acid signaling pathway

I

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GO:0007217 tachykinin signaling pathway

I

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GO:0007218 neuropeptide signaling pathway

I

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GO:0001789 G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating)

I

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GO:0001973 adenosine receptor signaling pathway

I

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GO:0031583 G-protein signaling, phospholipase D activating pathway

I

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GO:0031989 bombesin receptor signaling pathway

I

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GO:0016056 rhodopsin mediated signaling pathway

I

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GO:0007216 metabotropic glutamate receptor signaling pathway

P

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GO:0031684 heterotrimeric G-protein complex cycle

I

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GO:0060183 apelin receptor signaling pathway

NR

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GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway

PR

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GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway

Relationship key

Code Relationship

P part of

I is a

Protein Annotation

Help: filtering, analyzing and downloading annotation

1 Filtering Annotations

The filters beneath each of the column headings in annotation table can be clicked to specify filtering parameters, or to map annotations to sequence identifier types other than UniProtKB accessions. More advanced queries can be entered into the 'Advanced' text box.

2 Viewing Annotation Statistics

Statistics on the selected annotation set are available in the numbers adjacent to the 'Statistics' header.

3 Viewing Annotations

The annotation table defaults to displaying an initial 25 annotations, however this can be increased by changing the value adjacent to the 'Sample size' header. Alternatively, clicking the arrow at the bottom of the annotation table will advance the display to the next 25 annotations. Many of the values in the annotation table can be clicked on, and will provide further information and navigation options (this includes GO terms and sequence identifiers).

4 Downloading Annotations

An entire set of annotations can be downloaded in a text file from QuickGO by selecting 'Association format'. Users can select the file compression option (gzip) and the number of annotations to include.

Sample size:

4 Download

Options: gzip: limit:

Format: . Current columns, Tab Separated Values: .

Web service: annotation

Use this URI template to access this data as a service.

GAnnotation?format=tsv&limit=max-number-of-rows{&gz}{&q=advanced query}{&field=value{,value}}

Any number of fields can be specified, they will be AND'ed together. Any number of values can be specified for each field, they will be OR'ed together. Values should be URI encoded. Advanced query syntax and valid fields are listed in . Advanced query may only occur once and will be AND'ed with any other query criteria. Downloaded data will be in association format. The file will be truncated if more than the specified number of annotations are found. The file is roughly 70bytes/annotation (not gzipped). The file will be gzipped if the gz parameter is supplied. Sample clients are available in: java | bash | perl

Statistics

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.

Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.

Click on the 'Update' button to run the co-occurence calculation

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