Ph: 23009386
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clonidine - Substance Summary (SID: 163008)
An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine acts centrally by reducing sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure seen during rapid intravenous administration. (From Martindale, the Extra Pharmacopoeia, 30th ed, p350)
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Table of Contents
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Catapres [Boehringer Ingelheim Pharmaceuticals, Inc.]
CATAPRES-TTS is a transdermal system providing continuous systemic delivery of clonidine for 7 days at an approximately constant rate. Clonidine is a centrally acting alpha-agonist hypotensive agent. It is an imidazoline derivative with ...
Catapres [Boehringer Ingelheim Pharmaceuticals, Inc.]
Catapres (clonidine hydrochloride USP) is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of ...
Clonidine hydrochloride [Mutual Pharmaceutical Co., Inc.]
Clonidine hydrochloride USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free ...
Clonidine Hydrochloride [Mylan Pharmaceuticals Inc.]
Clonidine hydrochloride is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free ...
Clonidine Hydrochloride [Qualitest Pharmaceuticals]
Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free ...
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Drug and Chemical Info from MeSH: (Total:1)
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Properties Computed from Structure:
Molecular Weight 230.09386 [g/mol]
Molecular Formula C9H9Cl2N3
XLogP 2.7
H-Bond Donor 2
H-Bond Acceptor 3
Rotatable Bond Count 2
Tautomer Count 2
Exact Mass 229.017353
MonoIsotopic Mass 229.017353
Topological Polar Surface Area 36.4
Heavy Atom Count 14
Formal Charge 0
Complexity 222
Isotope Atom Count 0
Defined Atom StereoCenter Count 0
Undefined Atom StereoCenter Count 0
Defined Bond StereoCenter Count 0
Undefined Bond StereoCenter Count 0
Covalently-Bonded Unit Count 1
Descriptors Computed from Structure:
IUPAC Name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Canonical SMILES: C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
InChI: InChI=1/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)/f/h12,14H
Canonical SMILES: C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
InChI: InChI=1/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)/f/h12,14H
Substance Info:
SID: 163008
CID: 2803
Related Substances:
Similar Substances: 334 Links
Deposit Date: 2005-08-08
Modify Date: 2006-04-28
Modify Date: 2006-04-28
CID: 2803
Create Date: 2005-03-25
Related Substances:
Similar Substances: 334 Links
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