Zacopride
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Zacopride
Systematic (IUPAC) name
4-amino-N-(1-azabicyclo[2.2.2]octan-8-yl)-5-chloro-2-methoxybenzamide
Identifiers
ATC code ?
Chemical data
Mol. mass 309.791 g/mol
SMILES &
Synonyms Zacopride
Pharmacokinetic data
Therapeutic considerations
Routes ?
Zacopride is a potent antagonist at the 5HT3 receptor[1] and an agonist at the 5HT4 receptor.[2] It has anxiolytic[3] and nootropic effects in animal models,[4] with the (R) enantiomer being the more active form.[5] It also has antiemetic[6] and pro-respiratory effects, both reducing sleep apnoea[7] and reversing opioid-induced respiratory depression in animal studies.[8]
This pharmacology-related article is a stub. You can help Wikipedia by expanding it.[edit] References
^ Smith WW, Sancilio LF, Owera-Atepo JB, Naylor RJ, Lambert L. Zacopride, a potent 5-HT3 antagonist. Journal of Pharmacy and Pharmacology. 1988 Apr;40(4):301-2. PMID 2900319 ^ Lefebvre H, Contesse V, Delarue C, Soubrane C, Legrand A, Kuhn JM, Wolf LM, Vaudry H. Effect of the serotonin-4 receptor agonist zacopride on aldosterone secretion from the human adrenal cortex: in vivo and in vitro studies. Journal of Clinical Endocrinology and Metabolism. 1993 Dec;77(6):1662-6. PMID 8263156 ^ Costall B, Domeney AM, Gerrard PA, Kelly ME, Naylor RJ. Zacopride: anxiolytic profile in rodent and primate models of anxiety. Journal of Pharmacy and Pharmacology. 1988 Apr;40(4):302-5. PMID 2900320 ^ Fontana DJ, Daniels SE, Eglen RM, Wong EH. Stereoselective effects of (R)- and (S)-zacopride on cognitive performance in a spatial navigation task in rats. Neuropharmacology. 1996 Mar;35(3):321-7. PMID 8783207 ^ Young R, Johnson DN. Anxiolytic-like activity of R(+)- and S(-)-zacopride in mice. European Journal of Pharmacology. 1991 Aug 29;201(2-3):151-5. PMID 1686755 ^ Yamakuni H, Nakayama H, Matsui S, Imazumi K, Matsuo M, Mutoh S. Inhibitory effect of zacopride on Cisplatin-induced delayed emesis in ferrets. Journal of Pharmacological Sciences. 2006 May;101(1):99-102. PMID 16651699 ^ Carley DW, Depoortere H, Radulovacki M. R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats. Pharmacology, Biochemistry and Behaviour. 2001 May-Jun;69(1-2):283-9. PMID 11420096 ^ Meyer LC, Fuller A, Mitchell D. Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2006 Feb;290(2):R405-13. PMID 16166206
