Xanomeline
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Xanomeline
IUPAC name 3-(4-hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2H-pyridine
Identifiers
CAS number 131986-45-3
SMILES
CCCCCCOC1=NSN=C1C2=CCCN(C2)C
Properties
Molecular formula C14H23N3OS
Molar mass 281.42 g mol−1
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references
Xanomeline is a muscarinic agonist selective for the M1 subtype.[1] It has recently been studied in Europe for the cognitive and negative symptoms of Schizophrenia, and there were robust associated improvements in verbal learning and short-term memory. [2]
[edit] References
^ Farde L, Suhara T, Halldin C, et al (1996). "PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man". Dementia 7 (4): 187–95. PMID 8835881. ^ Am J Psychiatry. 2008 Aug;165(8):1033-9. Epub 2008 Jul 1. Links Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.Shekhar A, Potter WZ, Lightfoot J, Lienemann J, Dubé S, Mallinckrodt C, Bymaster FP, McKinzie DL, Felder CC.
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