U-89843A
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U-89843A
Systematic (IUPAC) name
6,7-dimethyl-2,4-dipyrrolidin-1-ylpyrrolo[3,2-e]pyrimidine
Identifiers
ATC code ?
Chemical data
Mol. mass 285.387 g/mol
SMILES &
Pharmacokinetic data
Therapeutic considerations
Legal status
Legal
Routes ?
U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.[1] It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.[2]
This pharmacology-related article is a stub. You can help Wikipedia by expanding it.[edit] References
^ Im HK, Im WB, Pregenzer JF, Carter DB, Hamilton BJ. U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. Journal of Pharmacology and Experimental Therapeutics. 1995 Dec;275(3):1390-5. PMID 8531107 ^ Bundy GL, Ayer DE, Banitt LS, Belonga KL, Mizsak SA, Palmer JR, Tustin JM, Chin JE, Hall ED, Linseman KL, et al. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. Journal of Medicinal Chemistry. 1995 Oct 13;38(21):4161-3. PMID 7473542
