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Talk:Time Release Technology (medicine)

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Contents

1 Talk Page 2 Patent stuff 3 Time control question 4 Terrible to start of with a confusion. 5 question need help

[edit] Talk Page

Welcome to the talk page of Sustained Release.--Delma1 12:06, 21 December 2006 (UTC)

[edit] Patent stuff

I copied the following from the main page (references section) as I have doubts about its usefulness in an encyclopedia. I'll research it more later, but for now... --Galaxiaad 08:24, 14 February 2007 (UTC)

http://www.pharmakodex.co.uk/technologies.html PharmaKodex has six proprietary technology platforms, five directed towards oral medicines… Pharmaceutical controlled release tablets containing a carrier made of cross-linked amylose and hydroxypropylmethylcellulose Document Type and Number: United States Patent 5885615 Link to this Page: http://www.freepatentsonline.com/5885615.html Abstract: Disclosed is a pharmaceutical controlled release tablet containing an active ingredient in combination with a carrier made of amylose used as a carrier, and thus to reduce the dependence of the kinetics of release upon the concentration of enzymes present in the medium. Immediate release tablet Document Type and Number: United States Patent 6521253 Link to this Page: http://www.freepatentsonline.com/6521253.html Abstract: A new oral IR formulation in solid form for a low molecular weight thrombin inhibitor having pH dependant dissolution, characterized in that the formulation comprises a filler or a combination of fillers having disintegrant properties in an amount higher than 35% w/w of the formulation. http://www.pharmcast.com/PatentToSubWeb/Classification/Classification1200.htm Controlled/Sustained/Delayed Release Drug Delivery System, General 1. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation 2. Once a day antihistamine and decongestant formulation…. up to 134. each one a clickable link. This looks a promising starting point. http://www.pharmaquality.com/mag/102005/pfq_102005_FO1.html gives an overview of gums / gels, used for even, slow release – describes the gum only, otherwise not informative. http://www.pharmcast.com/Patents100/Yr2004/Feb2004/022404/6696496_Venlafaxine022404.htm gives a detailed description of the patent used for slow-release Efexor. http://www.drugresourcecenter.com/kdur/kdur.htm Extended-Release Formulation for Liquid Suspension Potassium chloride liquid suspension is an oral dosage form of microencapsulated potassium chloride. Each packet contains 1.5 g of potassium chloride, USP equivalent to 20 mEq of ... Tech storm sweeps tableting http://www.pharmabiz.com/article/detnews.asp?articleid=21523&sectionid=50 Industrially Feasible Alternative Approaches in the Manufacture of Solid Dispersions: A Technical Report. A detailed academic paper on production of a delivery system.

[edit] Time control question

How finely can the release be controlled? Say, if I wanted a drug to be released only after eight hours, what would be the variance in the actual release time? Thanks. --Amit 12:46, 7 March 2007 (UTC)

That would be controlled release - sustained just means over extended periods of time. Release can be e.g. controlled from capsules. Either the complete capsule or a small part of it dissolve after a certain time and the drug is released completly or partially. —Preceding unsigned comment added by 70.45.146.25 (talk) 00:18, 6 August 2008 (UTC)

[edit] Terrible to start of with a confusion.

Sustained release is not the same as controlled release. Controlled means that the drug level is controlled - it can be pulsating etc. Sustained means that the drug is delievered for prolonged times (which can mean hours to months). I found a definition which I felt was more accurate than the statement in the article that states that the release rate has zero order kinetics (I challenge that statement!). Controlled release: Delivery of an agent at a controlled rate for an extended time. A controlled rate is not necessarily constant which is zero order.

Second, the article basically covers only conventional methods and drugs - not included is, e.g., micro- and nanosphere formulation with biocompatible polymers which is important for the delivery of many biodrugs (e.g., proteins).

When I have the time I include something here. I own many images of release formulations, such as micro- and nanospheres.

Dr. Kai Griebenow —Preceding unsigned comment added by 70.45.146.25 (talk) 00:24, 6 August 2008 (UTC)

Sustained release is not the same as controlled release. The page was started as discussing sustained release but was then expanded to include other forms Time Release medicines. I have moved the page to appropriate location. --Obsolete.fax (talk) 03:11, 3 November 2008 (UTC)

[edit] question need help

anyone can help to answer the difference between the sustained relaease versus the extended released? thanks very much for the help —Preceding unsigned comment added by 204.114.196.11 (talk) 13:35, 9 October 2008 (UTC)

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