Talk:Catecholamines

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[edit] INN vs BAN

I think it makes sense to use the INN (i.e. epinephrine) over the BAN (i.e. adrenaline). AFAIK, this is convention at WP-- see paracetamol (acetaminophen) and pethidine (meperidine). Nephron  T|C 06:01, 14 December 2006 (UTC)

The above suggestion is a valid point. I would like to say that I remember writing on this article when it was a stub and am guilty of using the BAN over the INN. This is a result of my being taught in the UK and raises another point. Of the younger users within the UK, very few will be able to identify Epinephrine as opposed to Adrenaline due to level of eductaion. In this case, I would suggest the use of "Epinephrine", but a note at the beginning stating that they are exactly the same. (Mubinchoudhury 22:06, 22 December 2006 (UTC))

I'm a first year university student and most UK-written physiology books now make a point of adrenaline and epinephrine being two ways of saying the same thing. I'd imagine most UK students can deduce this now a days. --Iscariot 23:26, 11 February 2007 (UTC)

Yes, INN is the standard here on wikipedia. I just had to revert some edits that changed the names back to BAN (i.e. "epinephrine" was changed to "adrenalin", "norepinephrine" was changed to "noradrenalin"). Fuzzform 01:53, 4 May 2007 (UTC)

[edit] Structure of NE (norepinephrine)

I was checking out the page and i see that NE has an OH at the bottom position, shouldn't it be at the upper left (3') position? I'm not 100% sure on the nomenclature but i think it goes counter clockwise (because of the doublebond)

If my nomenclature is right and since you can't change the conformation of a benzene ring and since all catecholamines should have hydroxyl groups at the 3' and 4' positions then that image should be updated

Thanks!

Prz36 05:18, 29 March 2007 (UTC) : )

EDIT: well i guess technically it doesnt matter (they both are right), but i do think epinephrine and norepinephrine should match in the way the structures look. thanks again Prz36 05:24, 29 March 2007 (UTC)

[edit] Serotonin

Any reason as why this isnt mentioned? --90.184.165.134 (talk) 16:16, 7 March 2008 (UTC) That would be me --David Munch (talk) 16:16, 7 March 2008 (UTC)

Yes... Seratonin isnt a catecholamine. It is uptaken via NAT transporters with epinepherine and is broken down using MAO, but it is not a catecholeamine. If memory serves me right, 5-HT is derived from tryptophan- an essential amino acid, but is not derived from tyrosine directly (so cannot be a catecholamine). It is however a Monoamine. --User:Mubinchoudhury —Preceding comment was added at 10:44, 27 April 2008 (UTC)

[edit] MAOI action of amphetamines

While I am aware that Selegeline, which has an amphetamine backbone, is an MAO-B inhibitor, I'm pretty sure that unsubstituted amphetamine is only a very weak MAOI, a weak synapse flow reverser and primarily is a DAT inhibitor (like Ritalin and cocaine). Moreover, meth's MAOI action is non-existent, its DAT binding is lower, and it mainly acts to reverse flow at the synapse (which is why it's potentially neurodegenerative - dopamine free radical build up inside the vesicle).

Could somebody clarify this in the "Degredation" section?

Furthermore, I'm unaware of any action on adrenaline for MAOIs and amphetamines. I guess it's possible, since adrenaline is built from norepinephrine, but I've just never seen it mentioned in literature. I'm interested in this, because, having ADHD, I wonder if it's just my norepinephrine and dopamine levels that they (stimulants and ADHD) change, or is it adrenaline, too? People with ADHD DO show blood-sugar abnormalities, so there's some weight to the idea, and as I said, adrenaline is built from noradrenaline, so it'd make sense that a roadblock at noradrenaline also limits supply of adrenaline. Most likely scenario is that adrenaline is ignored because it's not psychoactive.

Cheers. 210.215.140.180 (talk) 11:15, 29 August 2008 (UTC)

[edit] Lower catecholamines?

Anyone know of anything that can lower catecholamines? —Preceding unsigned comment added by Interestedperson (talk • contribs) 06:20, 13 October 2008 (UTC)