NK1 receptor antagonist
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Neurokinin NK1 antagonists are a novel class of medications that possesses unique antidepressant[1], anxiolytic[2], and antiemetic properties.
The NK2 and NK3 receptors are also targets for novel classes of medications, and also show prominent antidepressive and anxiolytic effects.[3]
[edit] See also
[edit] References
^ Varty GB, Cohen-Williams ME, Hunter JC (2003). "The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test". Behavioural pharmacology 14 (1): 87–95. doi:. PMID 12576885. ^ Varty GB, Cohen-Williams ME, Morgan CA, et al (2002). "The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists". Neuropsychopharmacology 27 (3): 371–9. doi:. PMID 12225694. ^ Salomé N, Stemmelin J, Cohen C, Griebel G (2006). "Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils". Pharmacol. Biochem. Behav. 83 (4): 533–9. doi:. PMID 16624395.
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